Results 151 to 160 of about 1,399,039 (262)

Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation. [PDF]

J Neural Eng
Liufu M, Leveroni ZM, Shridhar S, Zhou N, Yu JY.   +4 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Detection of Phase Randomly Distributed Weak Sinusoidal Signal Based on Autocorrelation Joint with Chaotic Oscillator Method

工程科学与技术, 2009
:In order to check the detection ability of chaotic oscillator system thoroughly, improve the detection performance and realize the detection of phase randomly distributed weak sinusoidal signal, the detection performance was studied by Monte- Carlo ...
doaj  

An Integrated TDR Waveguide and Data Interpretation Framework for Multi-Phase Detection in Soil-Water Systems. [PDF]

Sensors (Basel)
Wen S, Wu J, Guo Y.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Unsupervised learning for real-time and continuous gait phase detection. [PDF]

PLoS One
Anopas D, Wongsawat Y, Arnin J.
europepmc   +1 more source

Light phase detection with on-chip petahertz electronic networks. [PDF]

Nat Commun, 2020
Yang Y, Turchetti M, Vasireddy P, Putnam WP, Karnbach O, Nardi A, Kärtner FX, Berggren KK, Keathley PD.   +8 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Detection of explosive picric acid <i>via</i> ESIPT-inhibited fluorescent chemosensor: theoretical insights, vapour phase detection and flexible indicator design. [PDF]

RSC Adv
S P, Semwal K, S V, Salian RD, Kumbhakar P, Das AK.   +5 more
europepmc   +1 more source