Results 61 to 70 of about 1,399,039 (262)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Krawtchouk Moments for Gait Phase Detection [PDF]

open access: yes, 2014
We present a novel method for gait phase detection based on Krawtchouk moments, which can be used in gait analysis. The low computational cost and high capacity of description of the Krauchouk moments makes it easy detect the parameters of the gait cycle, such as the swing phase, stance phase and double support.
César Camacho-Bello   +1 more
openaire   +1 more source

An improved id-iq harmonic current detection algorithm for three-phase voltage asymmetry

open access: yesGong-kuang zidonghua, 2016
Due to phase angle measured by phase locked loop has phase difference with grid positive sequence fundamental voltage of traditional id-iq harmonic detection method in grid voltage asymmetry and distortion phase, at the same time, low pass filter ...
ZHOU Zhaoxian, CHEN Yonggang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Safety and Intranasal Retention of a Broad-Spectrum Anti-SARS-CoV-2 Monoclonal Antibody SA55 Nasal Spray in Healthy Volunteers: A Phase I Clinical Trial

open access: yesPharmaceutics
Background: A broad-spectrum anti-SARS-CoV-2 monoclonal antibody (mAb), SA55, is highly effective against SARS-CoV-2 variants. This trial aimed at demonstrating the safety, tolerability, local drug retention and neutralizing activity, systemic exposure ...
Chaoying Hu   +9 more
doaj   +1 more source

Improved Three-Phase AFD Islanding Detection Based on Digital Control and Non-Detection Zone Elimination

open access: yesEnergies, 2018
This paper proposes an improved active frequency drift (AFD) islanding detection method of a three-phase inverter. Different than the existing single-phase AFD method, in the three-phase system, the disturbance is added to the phase angle, which takes ...
Xinxin Zheng   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Experimental study on the mechanical properties and dry–wet–freeze–thaw coupled durability performance of hydraulic basalt fiber mortar

open access: yesFrontiers in Materials
Studying the effects of short-cut basalt fiber on the properties of hydraulic mortar and its damage mechanism under dry–wet–freeze–thaw coupling is essential for optimizing the mix proportion of hydraulic mortar applied to high-salt and high-altitude ...
Jianpeng Zhang   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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