Results 91 to 100 of about 1,904,886 (283)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Phase diagram of polymer electrolyte: (x)(PEO) – ( 1-x)CF3COOLi
Revista Facultad de Ingeniería Universidad de Antioquia, 2012 Solid polymer electrolytes based on poly(ethylene oxide) (PEO) and lithium trifluoroacetate (CF3COOLi) were prepared by a solvent casting method by different concentrations of salt.
Miguel Iban Delgado +2 more
doaj +3 more sources
Updating the phase diagram of the archetypal frustrated magnet Gd3Ga5O12
, 2015 The applied magnetic field and temperature phase diagram of the archetypal frustrated magnet, Gd3Ga5O12, has been reinvestigated using single crystal magnetometry and polarised neutron diffraction.
Deen, P. P. +3 more
core +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
On equilibration and coarsening in the quantum O(N) model at infinite $N$
, 2013 The quantum O(N) model in the infinite $N$ limit is a paradigm for symmetry-breaking. Qualitatively, its phase diagram is an excellent guide to the equilibrium physics for more realistic values of $N$ in varying spatial dimensions ($d>1$).
Chandran, Anushya +3 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
, 2006 Phase diagrams of [001] and [110] field-cooled (FC) (1-x)Pb(Mg1/3Nb2/3O3)-xPbTiO3 or PMN-xPT crystals have been constructed, based on high-resolution x-ray diffraction data. Comparisons reveal several interesting findings.
D. Viehland +7 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Unconventional superconducting phase diagram of monolayer WTe_{2}
Physical Review ResearchThe existence of a quantum critical point (QCP) and fluctuations around it are believed to be important for understanding the phase diagram in unconventional superconductors such as cuprates, iron pnictides, and heavy fermion superconductors.
Tiancheng Song +15 more
doaj +1 more source