Results 131 to 140 of about 11,707,174 (304)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

On the spatial phase distribution of cutaneous low-frequency perfusion oscillations. [PDF]

open access: yesSci Rep, 2022
Borik S   +5 more
europepmc   +1 more source

Approximation of Cumulative Distribution Functions by Bernstein Phase-Type Distributions

open access: yesPerformance Evaluation
The inclusion of generally distributed random variables in stochastic models is often tackled by choosing a parametric family of distributions and applying fitting algorithms to find appropriate parameters. A recent paper proposed the approximation of probability density functions (PDFs) by Bernstein exponentials, which are obtained from Bernstein ...
András Horváth   +4 more
openaire   +4 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Analysis of Parameters on the Phase Distribution of Debris Clouds in Hypervelocity Impacts

open access: yesSpace: Science & Technology
The phase distribution is a crucial aspect of the debris cloud’s characteristics. Solid-phase fragments maintain material strength and demonstrate superior penetration capabilities, whereas liquid- and gas-phase debris exhibit reduced penetration ...
Lvtan Chen   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

The Impact of Lipid Handling and Phase Distribution on the Acoustic Behavior of Microbubbles. [PDF]

open access: yesPharmaceutics, 2021
Langeveld SAG   +5 more
europepmc   +1 more source

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