Results 171 to 180 of about 4,565,563 (306)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Descriptors for Predicting Single- and Multi-Phase Formation in High-Entropy Oxides: A Unified Framework Approach. [PDF]

Materials (Basel)
Manchón-Gordón AF, Panadero-Medianero P, Blázquez JS.   +2 more
europepmc   +1 more source

Direct gas-phase formation of formic acid through reaction of Criegee intermediates with formaldehyde. [PDF]

Commun Chem, 2023
Luo PL, Chen IY, Khan MAH, Shallcross DE.   +3 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Influence of precursors and mineralizers on phase formation in ZrO₂ nanoparticles synthesized by the hydrothermal method. [PDF]

Sci Rep
Garanin Y, Shakirziyanov R, Borgekov D, Volodina N, Shlimas D, Zdorovets M.   +5 more
europepmc   +1 more source

Gas-phase formation of the resonantly stabilized 1-indenyl (C₉H₇^•) radical in the interstellar medium. [PDF]

Sci Adv, 2023
Yang Z, Galimova GR, He C, Goettl SJ, Paul D, Lu W, Ahmed M, Mebel AM, Li X, Kaiser RI.   +9 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Enhanced thermoelectric performance of yttrium-doped ZnO ceramics <i>via</i> secondary phase formation and conventional sintering. [PDF]

RSC Adv
Saleem A, Butt S, Irfan M, Masoud MF, Sumayya, Iqbal MU, Iqbal N, Khan AF, Basit MA.   +8 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Twice-Functionalized Montmorillonite Nanosheets for Polymer-Derived MMT-SiOC Nanocomposites: Phase Formation and Porosity. [PDF]

Small
Rau AV, Lu K.
europepmc   +1 more source