Results 221 to 230 of about 1,731,507 (269)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Probing Phase Formation and Structural Transformations in Sodium Extraction and Insertion of NaFe_1-yMn_yPO₄ through First-Principles Calculations. [PDF]

Inorg Chem
Ismail M, Lakuntza O, Carrasco J, Saurel D, Casas-Cabanas M, Reynaud M, Saracibar A.   +6 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Phase Formation during the Synthesis of the MAB Phase from Mo-Al-B Mixtures in the Thermal Explosion Mode. [PDF]

Materials (Basel)
Potanin AY, Bashkirov EA, Kovalev DY, Sviridova TA, Levashov EA.   +4 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Assessment of Secondary Sulfate Aqueous-Phase Formation Pathways in the Tropical Island City of Haikou: A Chemical Kinetic Perspective. [PDF]

Toxics
Wang C, Luo L, Xu Z, Liu S, Li Y, Ni Y, Kao SJ.   +6 more
europepmc   +1 more source

A Dynamically Induced Phase Transition in Na_<b>4</b>P_<b>2</b>S_<b>6</b>─Ultrafast Na^<b>+</b> Mobility Triggering Rotor Phase Formation. [PDF]

J Am Chem Soc
Hogrefe K, Gadermaier B, Schneider C, Bette S, Lotsch BV, Wilkening HMR.   +5 more
europepmc   +1 more source

Unconventional pathway for the gas-phase formation of 14π-PAHs <i>via</i> self-reaction of the resonantly stabilized radical fulvenallenyl (C₇H₅˙). [PDF]

Chem Sci
Li W, Wu M, Wang C, Huang J, Yang J, Xu M, Zhang F, Yang T, Zhao L.   +8 more
europepmc   +1 more source

Key phases in the formation of caveolae [PDF]

Current Opinion in Cell Biology, 2021
Caveolae are abundant plasma membrane pits formed by the coordinated action of peripheral and integral membrane proteins and membrane lipids. Here, we discuss recent studies that are starting to provide a glimpse of how filamentous cavin proteins, membrane-embedded caveolin proteins, and specific plasma membrane lipids are brought together to make the ...
Robert G. Parton, Vikas Tillu, Kerrie-Ann McMahon, Brett M. Collins   +3 more
openaire   +3 more sources

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Developmental Pattern Formation in Phases

Trends in Cell Biology, 2015
Cells in developing organs undergo a series of changes in their transcriptional state until a complete repertoire of cell types is specified. These changes in cell identity, together with the control of tissue growth, determine the pattern of gene expression in the tissue.
Anna, Kicheva, James, Briscoe
openaire   +2 more sources