Results 161 to 170 of about 17,664 (215)

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Structural basis for sarbecovirus Rc-o319 spike adaptation to Rhinolophus cornutus Bat ACE2 and constraints on switching to human ACE2. [PDF]

PLoS Pathog
Wang J, Li Z, Ma Y, Li Z, Yuan H, Niu C, Teng Y, Liu B, Li M, Zhou M, Liu W, Feng H, Chen J, He J, Chen X, Xiong X.   +15 more
europepmc   +1 more source

Bio‐Inspired Bidirectional Winding Origami With Programmable Modular Reconfigurability and Scalability

Advanced Science, EarlyView.
A bio‐inspired bidirectional‐winding origami platform enables scalable and programmable deployable structures. Double axial folding inspired by earwig hindwings and Flasher‐based hybridization create modular multilayer architectures with diverse attainable winding angles under fixed boundary conditions.
Wenyao Zhang, Chunlong Wang, Mingli Liu, Chuang Shi, Hongwei Guo, Rongqiang Liu   +5 more
wiley   +1 more source

Ferromagnet-like binary switching of a Stoner-Wohlfarth antiferromagnet. [PDF]

Nature
Wang Z, Xiang Y, Chen R, Sun Z, Hong C, Chen X, Gao J, Wu S, Guo Z, Chen Y, Mi Q, Liu Z, Yan S, Lei H, Ruan W, Zhang Y, Yu W, Liu WT, Yuan Z, Wu S.   +19 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

High-Precision Time-of-Arrival Estimation in HF Sensor Networks via Multipath Separation and Independent Tracking. [PDF]

Sensors (Basel)
Ji Q, Wu H.
europepmc   +1 more source

Ultrasound‐Activated Piezoelectric Neuroimmune Hydrogel Orchestrates Neurogenesis‐Macrophage Crosstalk in Diabetic Wound Healing

Advanced Science, EarlyView.
In this work, we design an ultrasound‐activated piezoelectric hydrogel platform (AOEF@AP5+US) that reprograms neurogenesis‐macrophage crosstalk as an integrated strategy to overcome the intertwined barriers of chronic inflammation, peripheral neuropathy, and impaired regeneration in diabetic wounds.
Kai Wang, Shaowen Zhuo, Binyu Song, Jinan Chen, Xin Zhao, Sijia Li, Shuang You, Dong Jiang, Yuedong Chen, Juanli Dang, Tong Wang, Baolin Guo, Zhou Yu, Baoqiang Song   +13 more
wiley   +1 more source

Active compensation of the AC Stark shift in a two-photon rubidium optical frequency reference using power modulation. [PDF]

Phys Rev Appl
Andeweg Y, Kitching J, Hummon MT.
europepmc   +1 more source

Surface and Interfacial Engineering toward Durable Mechanically Coupled Flexible Electronics

Advanced Science, EarlyView.
This Review highlights how surface and interfacial engineering governs the reliability, durability, and functional stability of mechanically coupled flexible electronics. By integrating fundamental interfacial theory, failure mechanisms, multiscale engineering strategies, and representative applications, it provides a design‐oriented framework for ...
Qian Wang, Fangfang Dai, Wei Wu
wiley   +1 more source

10^-21-Level optical frequency dissemination over 2067 km of noise-loaded field-deployed fiber network. [PDF]

Light Sci Appl
Chen FX, Li LB, Chen JP, Zhao K, Guan JY, Xu Y, Hou L, Zhou F, Peng CZ, Zhang Q, Jiang HF, Pan JW.   +11 more
europepmc   +1 more source