Results 71 to 80 of about 461,291 (268)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The supersolid phase of matter

Il Colle di Galileo, 2021
The supersolid is a phase of matter intermediate between a crystal and a superfluid. It was predicted more than fifty years ago, long sought in solid helium and only recently discovered in a quantum gas of magnetic atoms. This article explains how we came to discover the supersolid, how some surprising properties have already been characterized and ...
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Peculiar magnetotransport properties in epitaxially stabilized orthorhombic Ru3+ perovskite LaRuO3 and NdRuO3

Communications Materials
Complex oxides are interesting materials where multiple physical properties and functionalities can be realized by integrating different elements in a single compound.
Lingfei Zhang, Takahiro C. Fujita, Yuuki Masutake, Minoru Kawamura, Taka-hisa Arima, Hiroshi Kumigashira, Masashi Tokunaga, Masashi Kawasaki   +7 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Perfectly harmonic spin cycloid and multi-Q textures in the Weyl semimetal GdAlSi

Nature Communications
A fundamental question in condensed matter physics concerns how topological electronic states are influenced by many-body correlations, and magnetic Weyl semimetals represent an important material platform to address this problem.
Ryota Nakano, Rinsuke Yamada, Juba Bouaziz, Maurice Colling, Masaki Gen, Kentaro Shoriki, Yoshihiro Okamura, Akiko Kikkawa, Ryo Misawa, Priya R. Baral, Shunsuke Kitou, Yuiga Nakamura, Hiroyuki Ohsumi, Yoshikazu Tanaka, Hajime Sagayama, Hironori Nakao, Yuki Ishihara, Kamini Gautam, Oscar Fabelo, Yasujiro Taguchi, Youtarou Takahashi, Masashi Tokunaga, Taka-hisa Arima, Yoshinori Tokura, Ryotaro Arita, Jan Masell, Satoru Hayami, Max Hirschberger   +27 more
doaj   +1 more source

Terahertz spectroscopy on Faraday and Kerr rotations in a quantum anomalous Hall state

Nature Communications, 2016
Quantized magnetoelectric coupling, which induces exotic magneto-optical phenomena, awaits to be evidenced in topological insulators. Here, Okada et al.
Ken N. Okada, Youtarou Takahashi, Masataka Mogi, Ryutaro Yoshimi, Atsushi Tsukazaki, Kei S. Takahashi, Naoki Ogawa, Masashi Kawasaki, Yoshinori Tokura   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Strain-tuning for superconductivity in La3Ni2O7 thin films

Communications Physics
The recent discovery of high-transition temperature (T c) superconductivity in pressurized La3Ni2O7 bulk crystals has attracted keen attention for its characteristic energy diagram of e g orbitals containing nearly half-filled  $${d}_{{3}{z}^{2}-{r}^{2}}$
Motoki Osada, Chieko Terakura, Akiko Kikkawa, Masamichi Nakajima, Hsiao-Yi Chen, Yusuke Nomura, Yoshinori Tokura, Atsushi Tsukazaki   +7 more
doaj   +1 more source

Long-Range Nonstabilizerness and Phases of Matter

Physical Review Letters
Long-range nonstabilizerness can be defined as the amount of nonstabilizerness that cannot be removed by shallow local quantum circuits. We study long-range nonstabilizerness in the context of many-body quantum physics, a task with possible implications for quantum-state preparation protocols and implementation of quantum-error correcting codes.
Korbany, David Aram, Gullans, Michael J., Piroli, Lorenzo   +2 more
openaire   +4 more sources