Results 161 to 170 of about 5,106,399 (296)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Non-Volatile Phase Modulation with Ultralow Energy Consumption Enabled by 2D Ferroelectric/TMD Heterostructures. [PDF]

Adv Sci (Weinh)
Singh L, Guo S, Yang Y, Juperi S, Yu R, Gong X, Leong J, Lee SG, Wu Q, Ang LK, Chae SH.   +10 more
europepmc   +1 more source

Full 2π tunable phase modulation using avoided crossing of resonances. [PDF]

Nat Commun, 2022
Kim JY, Park J, Holdman GR, Heiden JT, Kim S, Brar VW, Jang MS.   +6 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Phase Modulation for Quadruplex Channels of Arbitrary Orthogonal Polarization States via Bilayer Metasurfaces. [PDF]

Nanophotonics
Wang W, Wang J, Wu Q, Lin J, Jin P, Liu S, Guo Z, Zhou K.   +7 more
europepmc   +1 more source

Arbitrary-Order and Multichannel Optical Vortices with Simultaneous Amplitude and Phase Modulation on Plasmonic Metasurfaces. [PDF]

Nanomaterials (Basel), 2022
Sun Q, Yang W, Jin L, Shangguan J, Wang Y, Cui T, Liang K, Yu L.   +7 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Analytical methods and Riccati neural networks method of Kudryashov's quintuple self-phase modulation with dual-form of generalized nonlocal nonlinearity. [PDF]

Sci Rep
Yu D, Manafian J, Abdalrahem MK, Lakestani M, Ilhan OA, Malmir S, Nuray R, Hammadi AH.   +7 more
europepmc   +1 more source

Integrated photonics enables continuous-beam electron phase modulation. [PDF]

Nature, 2021
Henke JW, Raja AS, Feist A, Huang G, Arend G, Yang Y, Kappert FJ, Wang RN, Möller M, Pan J, Liu J, Kfir O, Ropers C, Kippenberg TJ.   +13 more
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source