Results 171 to 180 of about 11,948,985 (352)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Optimal control in bounded phase space
Automatica, 1963 Abstract : A bounded phase space condition is derived for a restricted class of problems. The condition is proved to be a necessary condition for optimal control in a fixed time interval with free end point. If the system is linear, and the allowed regions of phase variables and controls are convex, the condition is both necessary and sufficient, for ...
openaire +2 more sources
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Phase retrieval via gain-based photonic XY-Hamiltonian optimization
Communications PhysicsPhase-retrieval from coded diffraction patterns (CDP) is important to X-ray crystallography, diffraction tomography and astronomical imaging, yet remains a hard, non-convex inverse problem.
Richard Zhipeng Wang +6 more
doaj +1 more source
Achievement of High Strength and Ductility in Al-Si-Cu-Mg Alloys by Intermediate Phase Optimization in As-Cast and Heat Treatment Conditions. [PDF]
Materials (Basel), 2020 Zhang B, Zhang L, Wang Z, Gao A.
europepmc +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
Incremental evolution strategy for function optimization
, 2006 This paper presents a novel evolutionary approach for function optimization Incremental Evolution Strategy (IES). Two strategies are proposed. One is to evolve the input variables incrementally.
Mo, W, Guan, SU
core
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
RF-MEMS switch actuation pulse optimization using Taguchi's method
, 2011 Copyright @ 2011 Springer-VerlagReliability and longevity comprise two of the most important concerns when designing micro-electro-mechanical-systems (MEMS) switches.
K. Tsiakmakis +7 more
core +1 more source