Results 41 to 50 of about 14,852,788 (203)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Big Ideas Exchange Highlights Struggle for Cyber Advantage [video]

, 2019
Naval Postgraduate School (NPS) faculty and students researching the cutting-edge of how the U.S. can gain an advantage in cyberspace shared their game-changing research during the latest Big Ideas Exchange (BIX), Nov.

core   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Phase-Contrast-Cine pulse sequence.

, 2017
Phase-Contrast-Cine pulse sequence to measure global and local pulse wave velocities (PWV). The sequence was repeated five times (segment loop) starting with a variable delay Δt = (0ms, 1ms, 2ms, 3ms, 4ms) thus yielding to an effective temporal ...
Peter Nordbeck (448724), Volker Herold (3753226), Peter M. Jakob (337273), Eberhard Rommel (3753232), Patrick Winter (3753235), Alexander Gotschy (3753229), Wolfgang R. Bauer (235378)   +6 more
core   +1 more source

Genomic evidence for the evolution of Streptococcus equi : host restriction, increased virulence, and genetic exchange with human pathogens [PDF]

, 2009
The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered. Streptococcus equi subspecies equi (S.
Parkhill Julian, Maskell, Duncan, Kehoe Michael, Robinson, Carl, Maiden, MC, Spratt, BG, Bason, Nathalie C., Aanensen, David M., Simmonds, M, Aanensen David M., Romain Paillot, Jourdan Thibaud, Willey, David, Maskell Duncan J., Aanensen, David, Katy Webb, Nathalie C Bason, Nancy E Holroyd, Ainslie, F, Maskell, DJ, Robinson Carl, Holden, Matthew, Simmonds Mark, Paillot Romain, Steward, KF, Jourdan, Thibaud, David M Aanensen, Bentley Stephen D., Jolley Keith A., Neil Chanter, Quail, Michael A., Stephen D Bentley, Webb, Katy, Holden, MT, Maiden Martin C. J., Julian Parkhill, Brooks Karen, Spratt Brian G., Maiden, MCJ, Fern Ainslie, Mark Simmonds, Keith A Jolley, Spratt, Brian, Holroyd, NE, Parkhill, Julian, Heather Zoe, Chanter, N, Michael Kehoe, Jolley, KA, David Willey, Bentley, Stephen, Ainslie, Fern, Quail, MA, Waller, Andrew S., Sanders Mandy, Waller, AS, Heather, Zoe, Waller, Andrew, Parkhill, J, Bason, NC, Sanders, M, Carl Robinson, Bason Nathalie C., Steward, Karen, Brooks, Karen, Bentley, Stephen D., Paillot, R, Wessels, Michael, Maiden, Martin, Holden, Matthew T. G., Zoe Heather, Robinson, C, Mungall Karen, Steward, Karen F., Quail Michael A., Paillot, Romain, Sanders, Mandy, Quail, Michael, Bason, Nathalie, Holroyd, Nancy, Maiden, Martin C. J., Andrew S Waller, Jolley, Keith A., Willey, D, Brian G Spratt, Chanter Neil, Mungall, K, Webb, K, Holden, MTG, Matthew T G Holden, Holroyd Nancy E., Kehoe, M, Karen F Steward, Maskell, Duncan J., Heather, Z, Holden Matthew T. G., Bentley, SD, Duncan J Maskell, Chanter, Neil, Aanensen, DM, Karen Brooks, Thibaud Jourdan, Brooks, K, Ainslie Fern, Steward Karen F., Holroyd, Nancy E., Mandy Sanders, Michael A Quail, Spratt, Brian G., Willey David, Simmonds, Mark, Waller Andrew S., Mungall, Karen, Webb Katy, Karen Mungall, Jourdan, T, Kehoe, Michael, Martin C J Maiden, Jolley, Keith   +118 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source