Results 61 to 70 of about 15,813,709 (209)

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Coalitional game with opinion exchange

, 2017
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2017.Cataloged from PDF version of thesis.Includes bibliographical references (pages 53-54).Traditional coalitional game theory does not apply if different ...
Jiang, Bomin
core  

Genomic evidence for the evolution of Streptococcus equi : host restriction, increased virulence, and genetic exchange with human pathogens [PDF]

, 2009
The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered. Streptococcus equi subspecies equi (S.
Parkhill Julian, Maskell, Duncan, Kehoe Michael, Robinson, Carl, Spratt, BG, Bason, Nathalie C., Aanensen, David M., Simmonds, M, Aanensen David M., Romain Paillot, Jourdan Thibaud, Willey, David, Maskell Duncan J., Aanensen, David, Katy Webb, Nathalie C Bason, Nancy E Holroyd, Ainslie, F, Maskell, DJ, Robinson Carl, Holden, Matthew, Simmonds Mark, Paillot Romain, Steward, KF, Jourdan, Thibaud, David M Aanensen, Bentley Stephen D., Jolley Keith A., Neil Chanter, Quail, Michael A., Stephen D Bentley, Webb, Katy, Maiden Martin C. J., Julian Parkhill, Brooks Karen, Spratt Brian G., Maiden, MCJ, Fern Ainslie, Mark Simmonds, Keith A Jolley, Spratt, Brian, Holroyd, NE, Parkhill, Julian, Heather Zoe, Chanter, N, Michael Kehoe, Jolley, KA, David Willey, Bentley, Stephen, Ainslie, Fern, Quail, MA, Waller, Andrew S., Sanders Mandy, Waller, AS, Heather, Zoe, Waller, Andrew, Parkhill, J, Bason, NC, Sanders, M, Carl Robinson, Bason Nathalie C., Steward, Karen, Brooks, Karen, Bentley, Stephen D., Paillot, R, Wessels, Michael, Maiden, Martin, Holden, Matthew T. G., Zoe Heather, Robinson, C, Mungall Karen, Steward, Karen F., Quail Michael A., Paillot, Romain, Sanders, Mandy, Quail, Michael, Bason, Nathalie, Holroyd, Nancy, Maiden, Martin C. J., Andrew S Waller, Jolley, Keith A., Willey, D, Brian G Spratt, Chanter Neil, Mungall, K, Webb, K, Holden, MTG, Matthew T G Holden, Holroyd Nancy E., Kehoe, M, Karen F Steward, Maskell, Duncan J., Heather, Z, Holden Matthew T. G., Bentley, SD, Duncan J Maskell, Chanter, Neil, Aanensen, DM, Karen Brooks, Thibaud Jourdan, Brooks, K, Ainslie Fern, Steward Karen F., Holroyd, Nancy E., Mandy Sanders, Michael A Quail, Spratt, Brian G., Willey David, Simmonds, Mark, Waller Andrew S., Mungall, Karen, Webb Katy, Karen Mungall, Jourdan, T, Kehoe, Michael, Martin C J Maiden, Jolley, Keith, Holden, Matthew T. G.; id_orcid   +117 more
core   +1 more source

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

FEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Big Ideas Exchange: The Struggle for Cyber Advantage [PDF]

, 2018
The Big Ideas Exchange (BIX) is an NPS initiative that brings forward new and potentially game-changing thinking developed by NPS faculty and students ot address grand challenges in American national security.Presentations: Tracking Anonymous Invaders ...

core   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Pulse sequences for measurement of magnetization exchange and effective 1H relaxation rates in condensed phase

<p>- ddHSQC based 4D pulse sequence for measurement of magnetization exchange in condensed phase samples, using gradients for coherence selection. Processing scripts for processing the data. </p> <p>- ddHMQC based 3D pulse sequence
Rangadurai, Atul, Kay, Lewis
core   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source