Results 21 to 30 of about 15,813,709 (209)

Population-associated differences between the phase variable LPS biosynthetic genes of Helicobacter pylori [PDF]

, 2006
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Salaün, L, Saunders Nigel J, Salaün Laurence, Saunders, NJ, Laurence Salaün, Nigel J Saunders, Saunders, Nigel J, Salaün, Laurence   +7 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Technology Exchange in Phase III of SMIP [PDF]

, 1998
Phase III (1993-98) of the SADC/ICRISAT Sorghum and Millet Improvement Program (SMIP), gave priority to promoting the transfer of improved technologies (primarily improved sorghum and pearl millet varieties) to small farmers.
Heinrich, G M
core  

Meningococcal genetic variation mechanisms viewed through comparative analysis of Serogroup C Strain FAM18 [PDF]

, 2007
Copyright @ 2007 Public Library of ScienceThe bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx.
Parkhill Julian, Snyder, L., Rabbinowitsch, Ester, Davis, P., Rabbinowitsch, E, Claire Arrowsmith, Saunders, Nigel, Saunders, Nigel J., Barrell, B, Chillingworth, Tracey, Moule, Sharon, Tracey Chillingworth, Unwin, L., Bentley Stephen D, Maddison Mark, Jagels Kay, Vernikos George S, Saunders Nigel J, Maddison, Mark, Quail Michael A, Jagels, K, Unwin, Louise, Davis Paul H, Nancy E Holroyd, Maddison, M, Jagels, K., Chillingworth Tracey, Moule, S., Achtman, M., Mark Achtman, Unwin Louise, Unwin, L, Chillingworth, T., Quail, Michael A., Sharp Sarah, Stephen D Bentley, Rabbinowitsch Ester, Vernikos, GS, Julian Parkhill, Snyder Lori A. S, Vernikos, G., Moule, S, Arrowsmith Claire, Holroyd, NE, Parkhill, Julian, Snyder, Lori A.S., Carol Churcher, Holroyd, N., Churcher, Carol, Quail, M., Davis, PH, Churcher Carol, Achtman, M, Barrell, Bart, Quail, MA, Bart Barrell, Mark Maddison, Chillingworth, T, Parkhill, J, Moule Sharon, Arrowsmith, C, Churcher, C, Whitehead, Sally, Bentley, Stephen D., Nigel J Saunders, Barrell Bart, Arrowsmith, Claire, Arrowsmith, C., Cronin, A, Whitehead, S., Achtman, Mark, Snyder, LAS, George S Vernikos, Ester Rabbinowitsch, Louise Unwin, Churcher, C., Barrell, B., Jagels, Kay, Cronin, Ann, Cronin, A., Whitehead Sally, Bentley, SD, Saunders, NJ, Kay Jagels, Holroyd Nancy E, Bentley, S., Sharp, Sarah, Sharp, S., Rabbinowitsch, E., Parkhill, J., Lori A S Snyder, Paul H Davis, Sharp, S, Sally Whitehead, Achtman Mark, Maddison, M., Holroyd, Nancy E., Vernikos, George S., Davis, Paul H., Michael A Quail, Saunders, N., Whitehead, S, Ann Cronin, Cronin Ann, Sharon Moule, Sarah Sharp   +105 more
core   +2 more sources

Hybrid Classical–Post-Quantum Migration Framework for Brownfield SCADA Environments

IEEE Access
Brownfield supervisory control and data acquisition environments face a migration problem that is materially different from enterprise information technology.
Ankit Gupta, Shilpi Mittal
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source