Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Retraction Notice to: Preparation, phase stability, and magnetization behavior of high entropy hexaferrites. [PDF]
Zhivulin VE +15 more
europepmc +1 more source
The multifaceted roles of lysosomes in cancer
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
Thermodynamics and Phase Stability of SmF<sub>3</sub> with LiF, NaF, and KF for Molten Salt Reactor Applications. [PDF]
Wilson JA +9 more
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Coverage-Dependent Phase Stability of Pb-Intercalated Buffer-Layer Graphene on SiC(0001). [PDF]
Han Y +4 more
europepmc +1 more source
Gas-phase stability and thermodynamics of ligand-bound, binary complexes of chloramphenicol acetyltransferase reveal negative cooperativity. [PDF]
Edwards AN +5 more
europepmc +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Phase stability and mechanical response of the ordered ScTaCo<sub>2</sub>Sb<sub>2</sub> crystal: insights from first-principles calculations. [PDF]
Guo Z +5 more
europepmc +1 more source
Brainwave Phase Stability: Predictive Modeling of Irrational Decision. [PDF]
Shan ZH.
europepmc +1 more source

