Results 151 to 160 of about 821,009 (292)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Oxygen Vacancy-Induced Phase Transformations of Iron-Doped Titanium Oxide Nanostructures. [PDF]

ACS Nano
Strapasson GB, Arjona AS, McPeak JE, Aalling-Frederiksen O, Sapnik AF, Baun NL, Bordallo HN, Rodella CB, Zanchet D, Jensen KMØ.   +9 more
europepmc   +1 more source

One Atom Can Make All the Difference: Gas-Induced Phase Transformations in Bisimidazole-Linked Diamondoid Coordination Networks. [PDF]

J Am Chem Soc, 2023
Koupepidou K, Nikolayenko VI, Sensharma D, Bezrukov AA, Vandichel M, Nikkhah SJ, Castell DC, Oyekan KA, Kumar N, Subanbekova A, Vandenberghe WG, Tan K, Barbour LJ, Zaworotko MJ.   +13 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Role of Stretching-Induced Phase Transformations in the Mechanical Properties of Isotactic 1‑Butene-ethylene Copolymers from Ziegler-Natta Catalyst. [PDF]

Macromolecules
Malafronte A, Di Girolamo R, Giordano A, De Stefano F, Scoti M, De Rosa C.   +5 more
europepmc   +1 more source

Structural Phase Transformations Induced by Guest Molecules in a Nickel-Based 2D Square Lattice Coordination Network. [PDF]

Chem Mater, 2023
Li X, Sensharma D, Nikolayenko VI, Darwish S, Bezrukov AA, Kumar N, Liu W, Kong XJ, Zhang Z, Zaworotko MJ.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Phase Transformations in MOFs Induced by Adsorbate Exchange. [PDF]

Langmuir
Neimark AV, Corrente NJ, Coudert FX.
europepmc   +1 more source

Investigations on the Phase Transformations, Equilibria and Athermal ω in Ni-Ga-Cr Ternary System. [PDF]

Materials (Basel), 2022
Ruan J, Chen Y, Kobayashi K, Ueshima N, Oikawa K.   +4 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source