Results 211 to 220 of about 3,197,248 (349)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Lenacapavir at the Spatiotemporal Limit: Tissue Pharmacokinetics, Pharmacokinetic Tail Dynamics, and the Emergence of Capsid Resistance in Long-Acting HIV Prevention. [PDF]

Clin Pharmacol
Chris-Uchendu HC, Olwit G, Atuhaire A, Matovu I, Kirumira HN, Sasiita PK, Odongo L, Mutekanga A, Nkwanga J.   +8 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Novel Design in Venturi-Type Nozzle by Selective Laser Melting for Enhancement in Microbubble Generation. [PDF]

Micromachines (Basel)
Chung M, Park C.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

The ESINEA Study: A Novel Screening Tool for Identifying Patient Safety Incidents and Adverse Events in Hospitalized Patients-An Index-Date Cohort Evaluation. [PDF]

Ther Clin Risk Manag
Dueñas Lopez FC, Fernández-Arroyo García A, Rivera Núñez MA, Díaz-Pollán B, Sobrino Jiménez C, Murillo Gayo C, Mendieta Azcona C, Jiménez Núñez C, Yagüe de Antonio G, Narrillos Martín I, Guijarro Eguinoa J, Ojeda Feo JJ, González de la Viuda MA, Bautista Reina MDC, Fernández Velilla Peña M, Jiménez-Gonzalez M, Duque Alcorta M, Álvarez-Montero M, González Muñoz M, Lorente Romeo M, Buitrago Sánchez NM, Rogozina O, López Ortego P, Pardo Puras R, Torres Santos Olmo RM, Iniesta Pérez S, Chajma Izquierdo S, Martín López S, Del Rosal T, Parra Ramírez P, Villán Villán YF, Martín Vega A, Ramírez E.   +32 more
europepmc   +1 more source

Multivariate Phase-type Distributions in Stochastic Modelling

This thesis concerns univariate and multivariate phase-type distribution with a focus on their usage in statistics. Chapters 1-3 serve as motivation and an introduction to the subject.
Gardner, Clara Brimnes
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Epidemiology of musculoskeletal injuries in Chinese collegiate dragon boat athletes: a cross-sectional survey. [PDF]

Front Public Health
Wang J, Ma H, Mu Z, Imai K, Yan H, Wang H, Han Z, Shen S, Zhou X, Yi L.   +9 more
europepmc   +1 more source