Results 41 to 50 of about 364,576 (288)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

FORMATION OF THE DIRECTION DIAGRAM IN PHASED ANTENNA ARRAY

Российский технологический журнал, 2019
The article presents the results of the study of phase and temporal methods in the formation of the direction diagram of phased antenna array, and carries out a comparative analysis using an eight-element equidistant antenna array based on Vivaldi ...
N. M. Legkiy, I. V. Unchenko
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A Design Proposal Using Coherently Radiating Periodic Structures (CORPSs) for 2-D Phased Arrays of Limited Scanning

Applied Sciences
New configurations of 2-D phased arrays are proposed in this paper for reducing the number of phase shifters. This design methodology is based on the use of a novel coherently radiating periodic structures (CORPSs) block for 2-D phased arrays.
Gilberto Calvillo, Marco A. Panduro, Elizvan Juarez, Alberto Reyna, Carlos del Rio   +4 more
doaj   +1 more source

Test Reduction for Power Density Emitted by Handset mmWave Antenna Arrays

IEEE Access, 2021
The exposure to electromagnetic field (EMF) from phased antenna arrays integrated into wireless devices operating at the millimeter-wave (mmWave) part of the spectrum should be evaluated in terms of power density (PD).
Stanislav Stefanov Zhekov, Kun Zhao, Ondrej Franek, Shuai Zhang   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Nonlinear phased array imaging [PDF]

SPIE Proceedings, 2016
A technique is presented for imaging acoustic nonlinearity within a specimen using ultrasonic phased arrays. Acoustic nonlinearity is measured by evaluating the difference in energy of the transmission bandwidth within the diffuse field produced through different focusing modes.
Croxford, Anthony, Cheng, Jingwei, Potter, Jack   +2 more
openaire   +2 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Optimization of Ultrasonic Phased Arrays [PDF]

, 1998
Ultrasonic phased arrays are an emerging technology in nondestructive evaluation (NDE) applications. A phased array is a multi-element piezo-electric device whose elements are individually excited by electric pulses at programmed delay times [1].
Wooh, Shi-Chang, Shi-Chang Wooh, Shi, Yijun, Yijun Shi   +3 more
core   +1 more source