Results 191 to 200 of about 1,240,122 (231)

What are the four phases of clinical research trials?

BMJ, 2014
Children with neurological and developmental disorders often experience chronic sleep disturbances. Melatonin has been commonly prescribed because of its hypnotic properties. However, trials have had conflicting results. Therefore, researchers assessed the effectiveness of melatonin in treating severe sleep problems in children with neurodevelopmental ...
P. Sedgwick
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The Drug Development Process and the Phases of Clinical Research

2007
A. Bacchieri, G. Cioppa
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A Brief Introduction to Phases of Clinical Medical Research for the SOF Medic

Journal of Special Operations Medicine, 2021
This is the first of an ongoing series to provide a background into reading medical research literature for the SOF medic.
Alex, Merkle, Josh, Randles
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Enhancing Traceability in Clinical Research Data through a Metadata Framework

Methods of Information in Medicine, 2020
Background The clinical research data lifecycle, from data collection to analysis results, functions in silos that restrict traceability. Traceability is a requirement for regulated clinical research studies and an important attribute of nonregulated ...
Sam Hume, Surendra Sarnikar, Cherie Noteboom   +2 more
semanticscholar   +1 more source

Continuity of Physician Participation in Phase I Clinical Research

Drug Information Journal, 1994
As the competition for research dollars becomes more keen, contract research organizations (CROs) are evolving into larger entities. As a result, Phase I units affiliated with CROs have grown in size andpersonnel in order to accommodate multiple studiesperformedsimultaneously.
Philip M. Brown, Joseph M. Scavone, Richard Ferraro   +2 more
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‘Risky’ research and participants' interests: the ethics of phase 2C clinical trials

Clinical Ethics, 2011
Biomedical research involving human participants is highly regulated and subject to stringent ethical requirements. Clinical research ethics, regulation and policy have tended to focus almost exclusively on the protection of participants' interests against harms that might result from taking part in research.
Chan, Sarah, Zee, Ying Kiat, Jayson, Gordon, Harris, John   +3 more
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An Example of a Clinical Research Ethics Committee in Türkiye: Types of Studies Analysed, Their Phases and Investigators

Journal of Empirical Research on Human Research Ethics
Clinical studies are reviewed by clinical research ethics committees (CRECs) in order to ensure that they are conducted within the framework of good clinical practice and that the rights of volunteers are respected.
Gungor Buket
semanticscholar   +1 more source

Prevalence, trends, and characteristics of trials investigating local therapy in contemporary phase 3 clinical cancer research

Cancer, 2023
AbstractBackgroundAlthough most patients with cancer are treated with local therapy (LT), the proportion of late‐phase clinical trials investigating local therapeutic interventions is unknown. The purpose of this study was to determine the proportion, characteristics, and trends of phase 3 cancer clinical trials assessing the therapeutic value of LT ...
Alexander D. Sherry, Kelsey L. Corrigan, Ramez Kouzy, Joseph Abi Jaoude, Yumeng Yang, Roshal R. Patel, Douglas J. Totten, Neil B. Newman, Prajnan Das, Cullen Taniguchi, Bruce Minsky, Rebecca A. Snyder, C. David Fuller, Ethan Ludmir   +13 more
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The Complexity of Consenting to Clinical Research in Phase I Pediatric Cancer Studies

Pediatric Drugs, 2015
The principal aim of phase I studies is to define the recommended dosing of drugs for phase II studies through assessment of drug pharmacokinetics and observation of the drug's toxicity profile. In the setting of pediatric oncology, the use of an experimental drug in phase I study is offered when prognosis is poor.
Tal, Schechter, Ronald, Grant
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