Results 31 to 40 of about 1,240,122 (231)

Post-COVID-19 Anosmia and Therapies: Stay Tuned for New Drugs to Sniff Out

Diseases, 2023
Background: Anosmia is defined as the complete absence of olfactory function, which can be caused by a variety of causes, with upper respiratory tract infections being among the most frequent causes.
Gabriele Riccardi, Giovanni Francesco Niccolini, Mario Giuseppe Bellizzi, Marco Fiore, Antonio Minni, Christian Barbato   +5 more
doaj   +1 more source

Clinical research on new drugs (Phase I). Profile of scientific publications: data from the pre-clinical phase and bioethical aspects [PDF]

Acta Cirurgica Brasileira, 2008
PURPOSE: To trace a profile of scientific publications, phase I, in order to know whether or not they show pre-clinical phase data, emphasizing bioethical aspects. METHODS: Sixty-one scientific articles, published in 2007, involving research in human beings using new drugs, medicines and vaccines during phase I were analysed.
Brick, Vanessa de Souza, Hossne, William Saad, Hossne, Rogério Saad   +2 more
openaire   +6 more sources

Toward a Standardized Strategy of Clinical Metabolomics for the Advancement of Precision Medicine [PDF]

, 2020
Despite the tremendous success, pitfalls have been observed in every step of a clinical metabolomics workflow, which impedes the internal validity of the study.
Kang, Yun Pyo, Kim, Hyung Min, Kwon, Sung Won, NGHI, TRAN, Nguyen Hoang Anh, Nguyen Phuoc Long, PARK, SANG KI   +6 more
core   +1 more source

Implementing a Standardized Language Evaluation in the Acute Phases of Aphasia: Linking Evidence-Based Practice and Practice-Based Evidence

Frontiers in Neurology, 2020
The research to practice gap is a significant problem across all disciplines of healthcare. A major challenge associated with the adoption of evidence into routine clinical care is the disconnect between findings that are identified in a controlled ...
Megan E. Schliep, Megan E. Schliep, Laura Kasparian, Olga Kaminski, Carla Tierney-Hendricks, Carla Tierney-Hendricks, Esther Ayuk, Lynne Brady Wagner, Semra Koymen, Sofia Vallila-Rohter, Sofia Vallila-Rohter   +10 more
doaj   +1 more source

P-hacking in clinical trials and how incentives shape the distribution of results across phases [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Statistical significance in clinical trials is a key prerequisite for marketing approval of new drugs. The large economic payoffs at stake might undermine investigators’ ethical obligations and incentivize manipulation of results. This study
J. Adda, C. Decker, M. Ottaviani
semanticscholar   +1 more source

Development and implementation of anxiety management program for women under gynecological surgery with spinal anesthesia: Protocol of action research study

Journal of Education and Health Promotion, 2022
BACKGROUND: Anxiety is the most common health problem and the second leading cause of disability worldwide. Patients undergoing surgery often experience anxiety. It is necessary to use appropriate interventions to achieve the best results.
Solmaz Halakou, Homeira Khoddam, Nasrin Nikpeyma, Mahnaz Modanloo   +3 more
doaj   +1 more source

The role of research in viral disease eradication and elimination programs: Lessons for malaria eradication [PDF]

, 2011
By examining the role research has played in eradication or regional elimination initiatives for three viral diseases-smallpox, poliomyelitis, and measles-we derive nine cross-cutting lessons applicable to malaria eradication.
Breman, JG, de Quadros, CA, Dowdle, WR, Foege, WH, Henderson, DA, John, TJ, Levine, MM   +6 more
core   +1 more source

Considerations for using distributed research networks to conduct aspects of randomized trials

Contemporary Clinical Trials Communications, 2020
Stakeholders in the clinical research enterprise are aligned around the need to make clinical research in general, and randomized controlled trials in particular, more meaningful and efficient.
Keith A. Marsolo, Jeffrey S. Brown, Adrian F. Hernandez, Bradley G. Hammill, Sudha R. Raman, Beth Syat, Richard Platt, Lesley H. Curtis   +7 more
doaj   +1 more source

Laboratory-Based SARS-CoV-2 Receptor Binding Domain Serologic Assays Perform with Equivalent Sensitivity and Specificity to Commercial FDA-EUA Approved Tests

Viruses, 2022
During early phases of the SARS-CoV-2 epidemic, many research laboratories repurposed their efforts towards developing diagnostic testing that could aid public health surveillance while commercial and public diagnostic laboratories developed capacity and
Mary Nehring, Sierra Pugh, Tina Dihle, Emily Gallichotte, Terry Nett, Eric Weber, Christie Mayo, Lori Lynn, Greg Ebel, Bailey K. Fosdick, Sue VandeWoude   +10 more
doaj   +1 more source

Qualitative analysis of clinical research coordinators' role in phase I cancer clinical trials

Contemporary Clinical Trials Communications, 2017
Clinical research coordinators play a pivotal role in phase I cancer clinical trials.We clarified the care coordination and practice for patients provided by clinical research coordinators in phase I cancer clinical trials in Japan and elucidated clinical research coordinators' perspective on patients' expectations and understanding of these trials ...
Noriko Fujiwara, Ryota Ochiai, Yuki Shirai, Yuko Saito, Fumitaka Nagamura, Satoru Iwase, Keiko Kazuma   +6 more
openaire   +3 more sources