Development and validation of the Trauma-Related Cognitions Scale.
PLoS ONE, 2021 Cognitive theories suggest the manner in which individuals process trauma-related information influences posttraumatic sequelae. Interpretations about trauma can be maladaptive and lead to cognitive distortions implicated in the development of ...
Christine E Valdez +3 more
doaj +1 more source
Inside Information: Financial Conflicts of Interest for Research Subjects in Early Phase Clinical Trials [PDF]
JNCI Journal of the National Cancer Institute, 2004 In recent years, several research subjects have told us that they had bought or intended to buy stock in the companies sponsoring the clinical trials in which they were enrolled. This situation has led us to ask what, if any, are physician-investigators' scientific, ethical, and legal responsibilities concerning research subjects who choose to buy ...
Epstein, Richard A. +3 more
openaire +3 more sources
Advances in the delivery of RNA therapeutics: from concept to clinical reality
Genome Medicine, 2017 The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression
James C. Kaczmarek +2 more
semanticscholar +1 more source
Fuzzy edge detection analysis of clinical drawing by schizophrenic patients
Journal of Human Environmental Studies, 2020 In this study, the fuzzy inference technique was applied for preprocessing the clinical drawings of schizophrenic patients. The interpretation procedure for the clinical drawings was divided into two phases, namely preprocessing and interpretation phases.
Keita Kawasugi +8 more
doaj +1 more source
Molecular Imaging-based Early-Phase and Exploratory Clinical Research
YAKUGAKU ZASSHI, 2013 In vivo molecular imaging became a key technology for innovative drug development. Especially, positron emission tomography (PET) has been applied to patho-physiological science, pharmacodynamics/pharmacokinetics (PD/PK) studies, and drug delivery system (DDS) studies, and accelerated the paradigm shift not only from experimental animals to human ...
openaire +4 more sources
HUMAN MICRO DOSING STUDIES (PHASE 0): A NOVEL APPROACH IN CLINICAL RESEARCH [PDF]
Journal of Pharmaceutical & Scientific Innovation, 2014 Micro dosing or Phase 0 clinical trial is a breakthrough in drug development , where sub therapeutic dosage s of various inv estigational product s are administered under necessary safety conditions to minimal n umber of volunteers in order to obtain an early pharmacokinetic profile of the product .
V R Manohar, Aravind Aiswarya
openaire +1 more source
Fluorescence optical imaging for treatment monitoring in patients with early and active rheumatoid arthritis in a 1-year follow-up period [PDF]
, 2019 BACKGROUND: Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies.
Backhaus, Marina +10 more
core +2 more sources
Racing against COVID-19: a vaccines strategy for Europe. Bruegel Policy Contribution Issue n˚7 | April 2020 [PDF]
, 2020 The fast development of vaccines is an essential part of the long-term solution to COVID-19, but vaccine development has high costs and carries the risk of high failure rates.
Veugelers, Reinhilde, Zachmann, Georg.
core +1 more source
Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium [PDF]
, 2019 Funding text The authors are grateful for the vital contributions of the participating study volunteers, clinicians, nurses, and laboratory technicians at the Surrey study site.
Bodinham, C. +16 more
core +1 more source
Is the timed-up and go test feasible in mobile devices? A systematic review [PDF]
, 2020 The number of older adults is increasing worldwide, and it is expected that by 2050 over 2 billion individuals will be more than 60 years old. Older adults are exposed to numerous pathological problems such as Parkinson’s disease, amyotrophic lateral ...
Garcia, Nuno +7 more
core +1 more source