Results 71 to 80 of about 1,240,122 (231)

Outcomes of Research Biopsies in Phase I Clinical Trials: The MD Anderson Cancer Center Experience [PDF]

The Oncologist, 2011
Abstract Background. Research biopsies are crucial for exploring the impact of novel agents on putative targets. The current study assesses the safety and success rate associated with performing such biopsies. Methods.
Hazem, El-Osta, David, Hong, Jennifer, Wheler, Siqing, Fu, Aung, Naing, Gerald, Falchook, Marshall, Hicks, Sijin, Wen, Apostolia M, Tsimberidou, Razelle, Kurzrock   +9 more
openaire   +2 more sources

Respiration-Induced Intraorgan Deformation of the Liver: Implications for Treatment Planning in Patients Treated With Fiducial Tracking. [PDF]

, 2017
Stereotactic body radiation therapy is a well-tolerated modality for the treatment of primary and metastatic liver lesions, and fiducials are often used as surrogates for tumor tracking during treatment. We evaluated respiratory-induced liver deformation
Anwar, Mekhail, Chang, Albert J, Descovich, Martina, Gottschalk, Alexander R, Paulsson, Anna K, Pinnaduwage, Dilini, Sudhyadhom, Atchar, Yom, Sue S   +7 more
core   +1 more source

Design-phase prediction of potential cancer clinical trial accrual success using a research data mart [PDF]

Journal of the American Medical Informatics Association, 2013
Many cancer interventional clinical trials are not completed because the required number of eligible patients are not enrolled.To assess the value of using a research data mart (RDM) during the design of cancer clinical trials as a predictor of potential patient accrual, so that less trials fail to meet enrollment requirements.The eligibility criteria ...
Jack W, London, Luanne, Balestrucci, Devjani, Chatterjee, Tingting, Zhan   +3 more
openaire   +2 more sources

Family coordination in families who have a child with autism spectrum disorder [PDF]

, 2018
Little is known about the interactions of families where there is a child with autism spectrum disorder (ASD). The present study applies the Lausanne Trilogue Play (LTP) to explore both its applicability to this population as well as to assess resources ...
A Lonigro, AA Hollingshead, AB Kelly, AH Rutgers, AS Carter, C Carneiro, C Kasari, C Lord, C Lord, C Trevarthen, CD Hoffman, CG Pottie, Christian Veronesi, D Oppenheim, D Oppenheim, D Steijn van, Diane Philipp, DN Stern, E Fivaz Depeursinge, E Fivaz Depeursinge, E Fivaz Depeursinge, E Sucksmith, EM Dykens, F Laghi, Fiorenzo Laghi, G Montes, G Vivanti, GM Griffith, I Marcu, II Fishman, J Cohen, J Duvekot, J McHale, J McHale, JL Taylor, JS Karst, L Adamson, L Oberman, Laura Vismara, LC Wynne, LE Libero, LE Marsh, M Ainsworth, M Losh, M Malagoli Togliatti, MH IJzendoorn Van, N Favez, N Favez, NO Davis, NV Ekas, P Fonagy, P Fonagy, PA Rao, PJ Curran, R Giallo, R Hoefman, R Phelps, RP Hastings, S Baron-Cohen, S Minuchin, S Rogers, Silvia Mazzoni, SSF Gau, T Cadman, U Frith   +64 more
core   +1 more source

Adaptive designs in clinical trials: why use them, and how to run and report them

BMC Medicine, 2018
Adaptive designs can make clinical trials more flexible by utilising results accumulating in the trial to modify the trial’s course in accordance with pre-specified rules.
P. Pallmann, A. Bedding, Babak Choodari-Oskooei, M. Dimairo, Laura Flight, Lisa V. Hampson, J. Holmes, A. Mander, Lang’o Odondi, M. Sydes, S. Villar, J. Wason, C. Weir, G. Wheeler, C. Yap, T. Jaki   +15 more
semanticscholar   +1 more source

Preliminary Results of the Louisiana Sex Offender Treatment Program [PDF]

, 2015
The purpose of this study was to offer preliminary support for the Louisiana Sex Offender Treatment Program (LSOTP) in addressing the needs of juvenile sex offenders.
Crump, Yolanda, Dailey, Frances L.L., Merino, Carrie, Underwood, Lee A.   +3 more
core   +3 more sources

Research biopsies in the context of early phase oncology studies: clinical and ethical considerations

Oncology Reviews, 2013
The Personalized Medicine approach in oncology is a direct result of an improved understanding of complex tumor biology and advances in diagnostic technologies. In recent years, there has been an increased demand for archival and fresh tumor analysis in early clinical trials to foster proof-of-concept biomarker development, to understand resistance ...
Matilde Saggese, Divyanshu Dua, Emily Simmons, Charlotte Lemech, Hendrik-Tobias Arkenau   +4 more
openaire   +3 more sources

The iBRA (implant breast reconstruction evaluation) study: protocol for a prospective multi-centre cohort study to inform the feasibility, design and conduct of a pragmatic randomised clinical trial comparing new techniques of implant-based breast reconstruction. [PDF]

, 2016
BACKGROUND: Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure in the UK. The introduction of techniques to augment the subpectoral pocket has revolutionised the procedure, but there is a lack of high ...
Barnes, NL, Blazeby, JM, Branford, OA, Breast Reconstruction Research Collaborative, Conroy, EJ, Cutress, RI, Gardiner, MD, Holcombe, C, Jain, A, McEvoy, K, Mills, N, Mylvaganam, S, Potter, S, Skillman, JM, Teasdale, EM, Thrush, S, Whisker, LJ, Williamson, PR   +17 more
core   +5 more sources

Racing against COVID-19: a vaccines strategy for Europe. Bruegel Policy Contribution Issue n˚7 | April 2020 [PDF]

, 2020
The fast development of vaccines is an essential part of the long-term solution to COVID-19, but vaccine development has high costs and carries the risk of high failure rates.
Veugelers, Reinhilde, Zachmann, Georg.
core   +1 more source

Advances in the delivery of RNA therapeutics: from concept to clinical reality

Genome Medicine, 2017
The rapid expansion of the available genomic data continues to greatly impact biomedical science and medicine. Fulfilling the clinical potential of genetic discoveries requires the development of therapeutics that can specifically modulate the expression
James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson   +2 more
semanticscholar   +1 more source