Results 81 to 90 of about 625,308 (190)

Translational pathway of a novel PFF2 respirator with chitosan nanotechnology: from the concept to the practical applications

Frontiers in Nanotechnology
Introduction:Translational Health Research (THR) is a tool aimed at assisting in the transformation of basic and/or applied scientific research into a health technology ready for commercialization.
Mário Fabrício Fleury Rosa, Mário Fabrício Fleury Rosa, Leonor Maria Pacheco Santos, Carlos Augusto Grabois Gadelha, Carlos Augusto Grabois Gadelha, Aline Martins de Toledo, Rodrigo Luiz Carregaro, Ana Karoline Almeida da Silva, Lindemberg Barreto Mota da Costa, Adson Ferreira da Rocha, Adson Ferreira da Rocha, Suélia de Siqueira Rodrigues Fleury Rosa, Suélia de Siqueira Rodrigues Fleury Rosa   +12 more
doaj   +1 more source

Embedding a commitment to equitable global access into basic and early-phase translational research

Journal of Clinical and Translational Science
The COVID-19 pandemic laid bare the inequities in U.S. healthcare in ways that captured public attention and reinforced the need to view all of healthcare through an equity lens. It also exposed global inequities in access to healthcare technologies.
Barry S. Coller
doaj   +1 more source

The Osteogenic Peptide P-15 for Bone Regeneration: A Narrative Review of the Evidence for a Mechanism of Action

Bioengineering
Bone regeneration is a complex multicellular process involving the recruitment and attachment of osteoprogenitors and their subsequent differentiation into osteoblasts that deposit extracellular matrixes.
Cooper T. Cheng, Praveer S. Vyas, Edward James McClain, Thomáy-Claire Ayala Hoelen, Jacobus Johannes Chris Arts, Colin McLaughlin, Daniel T. Altman, Alexander K. Yu, Boyle C. Cheng   +8 more
doaj   +1 more source

Longitudinal phase 2 clinical trials of live, attenuated tularemia vaccine in healthy research laboratory workers

Frontiers in Bacteriology
BackgroundTularemia is caused by the intracellular bacterium Francisella tularensis (Ft). It was weaponized historically due to low infectious aerosol dose, high morbidity, and mortality rates for pneumonic disease. The US Army developed the attenuated Live Vaccine Strain (LVS) from stocks provided by the former Soviet Union in the 1950s.
David L. Saunders, Benjamin C. Pierson, Jeannine Haller, Sarah Norris, Anthony P. Cardile, Ronald B. Reisler, Arthur C. Okwesili, Ellen Boudreau, Janice Rusnak, Denise K. Danner, Bret K. Purcell, James F. Barth, Erin L. Tompkins, Isaac L. Downs, Dani Liggett, Patricia Pettit, Tami Pratt, Mark Goldberg, Mark G. Kortepeter, Fernando B. Guerena, John W. Aldis, Maryam Keshtkar-Jahromi, Phillip R. Pittman   +22 more
openaire   +1 more source

Overview of ethical issues for conducting neuroprotective clinical trials in patients with spinal cord injury

Journal of Neurorestoratology, 2015
Hooshang Saberi,1,2 Nazi Derakhshanrad,1 Mahsa Ghajarzadeh1 1Brain and Spinal Cord Injury Research Center, Imam Khomeini Hospital, 2Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Abstract: Animals
Saberi H, Derakhshanrad N, Ghajarzadeh M
doaj  

Yesterday, today and tomorrow of Duchenne muscular dystrophy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2015
The research history of Duchenne muscular dystrophy (DMD) may be roughly divided into 3 phases: clinical describing (1836-1985), molecular diagnosis and exploratory therapy (1985-2020), and the pathogenesis illuminating, gene therapy or treatment against
Cheng ZHANG
doaj  

The role of reference intervals of laboratory tests in early phase clinical research in healthy volunteers

Качественная клиническая практика, 2018
This article discusses one of the most disputable issues in national clinical research practice in healthy volunteers. Regulatory requirements forbid to assess even minor deviations of laboratory parameters from reference intervals as not clinically significant.
Fitilev S.B., Vozzhaev A.V., Shkrebniova I.I., Kliuev D.A., Vdovina A.A., Miasnikova L.A.   +5 more
openaire   +2 more sources

Failure to consider the menstrual cycle phase may cause misinterpretation of clinical and research findings of cardiometabolic biomarkers in premenopausal women.

Epidemiologic Reviews, 2014
E. Schisterman, S. Mumford, L. Sjaarda
semanticscholar   +1 more source

Investigational new drugs and ethical review: the adequacy of clinical research phases

, 2007
A avaliação prévia por um Comitê de Ética em Pesquisa de todos os projetos de pesquisa envolvendo seres humanos é uma garantia contra eventuais abusos que possam vir a ser propostos. A pesquisa com novas drogas é das que mais requerem cuidados no processo de avaliação, especialmente por que se desenvolvem em diferentes fases conforme o nível de ...
openaire   +1 more source

Sample size calculations in clinical research.

Anesthesiology, 2002
P. Bacchetti, J. Leung
semanticscholar   +1 more source