Results 131 to 140 of about 1,628,623 (339)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Streaming Event-Triggered Point-on-Wave Measurements for Disturbance Monitoring and Analysis

IEEE Access
Phasor measurements become unreliable during power system disturbances due to nonsinusoidal waveform distortions, particularly in grids with high penetration of inverter-based resources (IBRs).
Kaustav Chatterjee, Jim Follum
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Determination of carotene, tocopherols and tocotrienols in residue oil from palm pressed fiber using pressurized liquid extraction-normal phase liquid chromatography

, 2005
Mohd Marsin Sanagi, Hong Heng See, Wan Aini Wan Ibrahim, Ahmedy Abu Naim   +3 more
openalex   +1 more source

Reborn Mechanism: Rethinking the Negative Phase Information Flow in Convolutional Neural Network [PDF]

, 2021
Zhicheng Cai, Kaizhu Huang, Chenglei Peng   +2 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Finite element modeling of surface acoustic wave propagation in polycrystalline aluminium: effective phase velocity

, 2020
Martin Ryzy, Tomáš Grabec, István A. Veres   +2 more
openalex   +2 more sources

The phase angle is associated with upper arm muscle circumference but not with sarcopenia in continuous ambulatory peritoneal dialysis patients [PDF]

, 2022
Ye Chen, Jinlan Wu, Lei Ran, Dan Yu, Xi Chen, Maodong Liu   +5 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Sheath Voltage Limiter Defects Detection Method Based on Harmonic Phasor Differences of Sheath Current for Cross-Bonded HV Cable

IEEE Access
The sheath voltage limiter (SVL) defect is a typical defect in HV cable cross-bonding systems that threatens cable system safety. Traditional surge arrester detection and time-domain sheath current analysis methods fail to accurately identify SVL defects
Hao Hu, Jing Tu, Yongheng Ai, Zhanran Xia, Ruoxin Song, Bin Yang, Xinyun Gao, Zhi Li, Fuyuan Liu, Hang Wang   +9 more
doaj   +1 more source