Results 141 to 150 of about 1,628,623 (339)

A Phase II Study of Dose-Intensified Chemoradiation Using Biologically-Based Target Volume Definition in Patients with Newly Diagnosed Glioblastoma

, 2020
M.M. Kim, Yihan Sun, Madhava Aryal, Hemant Parmar, Morand Piert, B.S. Rosen, C. Mayo, J Balter, M. Schipper, Nicolette Gabel, Emily M. Briceño, D. You, Jason Heth, Wajd N. Al‐Holou, Yoshie Umemura, Denise Leung, Larry Junck, D.R. Wahl, Theodore S. Lawrence, Yang Cao   +19 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Phasor-FSTM: a new paradigm for multicolor super-resolution imaging of living cells based on fluorescence modulation and lifetime multiplexing

Light: Science & Applications
Multicolor microscopy and super-resolution optical microscopy are two widely used techniques that greatly enhance the ability to distinguish and resolve structures in cellular imaging.
Luwei Wang, Yue Chen, Jiaqing Guo, Xiaoyu Weng, Wei Yan, Jun Song, Tong Ye, Junle Qu   +7 more
doaj   +1 more source

In-cloud processes of methacrolein under simulated conditions – Part 1: Aqueous phase photooxidation

, 2009
Yao Liu, Imad El Haddad, M. Scarfogliero, L. Nieto-Gligorovski, Nicolas Marchand, Brice Temime‐Roussel, Etienne Quivet, B. Picquet-Varrault, Anne Monod   +8 more
openalex   +1 more source

The acute-phase protein alpha 1-antitrypsin inhibits growth and proliferation of human early erythroid progenitor cells (burst-forming units-erythroid) and of human erythroleukemic cells (K562) in vitro by interfering with transferrin iron uptake [PDF]

, 1994
I Graziadei, S. Gaggl, R Kaserbacher, H Braunsteiner, W. Vogel   +4 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Correction: Vedolizumab in Japanese patients with ulcerative colitis: A Phase 3, randomized, double-blind, placebo-controlled study

, 2019
Satoshi Motoya, Kenji Watanabe, Haruhiko Ogata, Takanori Kanai∥, Toshiyuki Matsui, Yasuo Suzuki, Mitsuhiro Shikamura, Kenkichi Sugiura, Kazunori Oda, Tetsuharu Hori, Takahiro Araki, Mamoru Watanabe, Toshifumi Hibi∥   +12 more
openalex   +1 more source

Erratum to: Phase II Study of Gemcitabine and Erlotinib as Adjuvant Therapy for Patients with Resected Pancreatic Cancer [PDF]

, 2011
Philip Bao, Ramesh K. Ramanathan, Alyssa Krasinkas, Nathan Bahary, Barry C. Lembersky, David L. Bartlett, Steven J. Hughes, Kenneth K. Lee, A. James Moser, Herbert J. Zeh   +9 more
openalex   +1 more source

Enhancing single-arm phase II trials by inclusion of matched control patients [PDF]

, 2020
Johannes Krisam, Dorothea Weber, Richard F. Schlenk, Meinhard Kieser   +3 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source