Results 141 to 150 of about 7,565,239 (380)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Ceftobiprole Compared With Vancomycin Plus Aztreonam in the Treatment of Acute Bacterial Skin and Skin Structure Infections: Results of a Phase 3, Randomized, Double-blind Trial (TARGET) [PDF]

, 2020
J. Scott Overcash, Charles Kim, Richard Keech, Illia Gumenchuk, Borislav Ninov, Yaneicy Gonzalez‐Rojas, Michael F. Waters, S Simeonov, Marc Engelhardt, Mikael Saulay, Daniel Ionescu, Jennifer I. Smart, Mark E. Jones, Kamal Hamed   +13 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Streaming Event-Triggered Point-on-Wave Measurements for Disturbance Monitoring and Analysis

IEEE Access
Phasor measurements become unreliable during power system disturbances due to nonsinusoidal waveform distortions, particularly in grids with high penetration of inverter-based resources (IBRs).
Kaustav Chatterjee, Jim Follum
doaj   +1 more source

The initial phases of the 2008–2009 Mount Etna eruption: A multidisciplinary approach for hazard assessment [PDF]

, 2011
Alessandro Bonaccorso, Alessandro Bonforte, Sonia Calvari, Ciro Del Negro, Giuseppe Di Grazia, Gaetana Ganci, Marco Neri, Annamaria Vicari, E. Boschi   +8 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Sheath Voltage Limiter Defects Detection Method Based on Harmonic Phasor Differences of Sheath Current for Cross-Bonded HV Cable

IEEE Access
The sheath voltage limiter (SVL) defect is a typical defect in HV cable cross-bonding systems that threatens cable system safety. Traditional surge arrester detection and time-domain sheath current analysis methods fail to accurately identify SVL defects
Hao Hu, Jing Tu, Yongheng Ai, Zhanran Xia, Ruoxin Song, Bin Yang, Xinyun Gao, Zhi Li, Fuyuan Liu, Hang Wang   +9 more
doaj   +1 more source

Thermal performance of concrete bricks based phase change material encapsulated by various aluminium containers: An experimental study under Iraqi hot climate conditions

, 2021
Qudama Al-Yasiri, Márta Szabó
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source