Results 191 to 200 of about 1,628,623 (339)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cancer cell identification in tissue imaging via phasor map analysis in polarization-resolved two-photon excitation fluorescence microscopy. [PDF]

Biomed Opt Express
Mohebi A, Mortensen LB, Untracht GR, Veettikazhy M, Le Gratiet A, Andersen PE.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Chemical fluorophores for fluorescence lifetime imaging. [PDF]

Chem Soc Rev
Lim C, Seah D, Vendrell M.
europepmc   +1 more source

From Relativistic Electrons To X-Ray Phase Contrast Imaging [PDF]

, 2018
A.H. Lumpkin, A. B. Garson, Mark A. Anastasio   +2 more
openalex   +1 more source

Net Energy Gain from a Berry Geometrical Phase – Low-Energy Perturbations of the Strong Interaction and the QCD Mass Gap

, 2023
Mark Gibbons
openalex   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Phasor theory of fluorescence lifetime imaging utilized on a maximum range of frequencies for prostate tissue analysis. [PDF]

Biomed Opt Express
Schoop RAL, de Roode LM, Alfonso-García A, Fereidouni F, de Boer LL, Marcu L, Ruers TJM.   +6 more
europepmc   +1 more source

Anisotropic viscoelastic phase separation in polydisperse hard rods: non-sticky gelation [PDF]

, 2018
Claudia Ferreiro-Córdova, C. Patrick Royall, Jeroen S. van Duijneveldt   +2 more
openalex   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source