HSP70 governs permeability and mechanotransduction in primary human endothelial cells
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Insights into de-mixing and morphology modulation in coacervate-membrane interactions from integrating experiments and simulations. [PDF]
Mondal S +3 more
europepmc +1 more source
A Novel Method for Phasor Measurement Unit Sampling Time Error Compensation
Wenxuan Yao +6 more
semanticscholar +1 more source
Alliance A022104/NRG-GI010: The Janus Rectal Cancer Trial: a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free survival in patients with locally advanced rectal cancer [PDF]
Janet Alvarez +29 more
openalex +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Chemical fluorophores for fluorescence lifetime imaging.
Lim C, Seah D, Vendrell M.
europepmc +1 more source
Unmixing Hyperspectral SRS Images in the Cell-Silent Region of the Raman Spectrum Using Phasor Analysis. [PDF]
Tipping WJ +3 more
europepmc +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
FLIMPA: A Versatile Software for Fluorescence Lifetime Imaging Microscopy Phasor Analysis. [PDF]
Kapsiani S +5 more
europepmc +1 more source

