Results 71 to 80 of about 4,563,019 (245)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Phasor Measurement Unit Based on Robust Dynamic State Estimation in Power Systems Using M-Estimators [PDF]

, 2014
This paper introduces the uses of Robust Dynamic State Estimation (RDSE) with Phasor Measurement Unit (PMU), The M-Estimators Quadratic Linear (QL) and Square Root (SR) Estimators have been used.
Li, Gengyin, Dowi, Sideig Abdelrhman
core   +1 more source

Inverter Model Validation and Calibration Using Phasor Measurement Unit Data

IEEE Access
As the penetration of inverter-based renewable energy resources increases in the power grid, especially at the distribution and microgrid levels, the need to accurately represent them in planning studies increases as well.
Shuchismita Biswas, Francis Tuffner, Jim Follum, Todd Wall   +3 more
doaj   +1 more source

A Synchrophasor Based Optimal Voltage Control Scheme with Successive Voltage Stability Margin Improvement

Applied Sciences, 2016
This paper proposes an optimal control scheme based on a synchronized phasor (synchrophasor) for power system secondary voltage control. The framework covers voltage stability monitoring and control.
Heng-Yi Su, Yi-Chung Chen, Yu-Liang Hsu
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Protection of Microgrid Feeders Using Impedance Angle Analysis Assisted by Synchrophasor Units [PDF]

Journal of Renewable Energy and Environment
The healthy operation of a microgrid is a more challenging task due to the inclusion of various distribution generation (DG) sources. The incorporation of a grid with various distributed sources alters the radial structure of the network, making it ...
Sunil Kumar, Ikbal Ali, Anwar Siddiqui
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Influence of measurement uncertainty propagation in current-channel-selectable multi objective optimal phasor measurement unit placement problem [PDF]

, 2019
This paper proposes current-channel-selectable multi objective optimal Phasor Measurement Unit (PMU) placement problem with measurement uncertainty propagation.
Mitani, Yasunori, Othman, Mohammad Lutfi, Matsukawa, Yoshiaki, Watanabe, Masayuki, M. L. Othman, Y. Matsukawa, Y. Mitani, M. Watanabe   +7 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source