Results 201 to 210 of about 5,236 (217)

Antimicrobial activities of phenethyl isothiocyanate isolated from horseradish

Natural Product Research, 2012
Phenethyl isothiocyanate (PEITC) was obtained from horseradish. The preparation procedure was as follows: the horseradish powder was hydrolysed in the water first, and then, after filtration, the residue was extracted by petroleum ether; finally, PEITC was isolated by silica gel column.
Hongxia, Chen, Chengzhang, Wang, Jianzhong, Ye, Hao, Zhou, Xijuan, Chen   +4 more
openaire   +2 more sources

Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate

Bioorganic & Medicinal Chemistry Letters, 2000
N-(N'-Phenethylthiocarbamoyl) derivatives of sphingosine and sphinganine were prepared. They had antitumour activity: GC50 values of 0.64+/-0.02 microM (N = 18) and 1.6+/-0.01 microM (N = 18). respectively, with human leukaemia 60 cells in vitro.
K, Xu, P J, Thornalley
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Effects of Phenethyl Isothiocyanate on Acetaminophen Metabolism and Hepatotoxicity in Mice

Toxicology and Applied Pharmacology, 1997
Phenethyl isothiocyanate (PEITC), a compound derived from cruciferous and other vegetables, is a potent inhibitor of cytochrome P450 2E1. This enzyme catalyzes the bioactivation of acetaminophen (APAP) and many other xenobiotics. The present study investigated the effects of PEITC on APAP metabolism and associated hepatotoxicity in Swiss-Webster mice ...
Y, Li, E J, Wang, L, Chen, A P, Stein, K R, Reuhl, C S, Yang   +5 more
openaire   +2 more sources

Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450

Archives of Toxicology, 2010
Phenethyl isothiocyanate is a chemopreventive phytochemical present in cruciferous vegetables where it exists as the glucosinolate gluconasturtiin. It is a mechanism-based inhibitor of both rat and human cytochrome P450 enzymes. The principal objective of the present study was to ascertain whether phenethyl isocyanate, formed by the cytochrome P450 ...
Konsue, N, Ioannides, C
openaire   +3 more sources

Distribution and metabolism of the natural anticarcinogen phenethyl isothiocyanate in A/J mice

Carcinogenesis, 1990
The distribution and metabolism of phenethyl isothiocyanate (PEITC), a naturally occurring anticarcinogen, was investigated in A/J mice. Mice were administered 5 mumol of [14C]PEITC (2 microCi/mouse) by gavage and killed at 1, 2, 4, 8, 24, 48 or 72 h after dosing.
K I, Eklind, M A, Morse, F L, Chung
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Phenethyl Isothiocyanate in Breast Cancer Prevention

2004
Abstract : Our hypothesis is that PEITC is an effective preventive agent in breast cancer. Although a number of mechanisms may be involved, one mechanism of PEITC effects that has not been explored is the potential for PEITC to alter the synthesis and elimination of estrogens.
openaire   +1 more source

Induction of apoptosis by phenethyl isothiocyanate in cells overexpressing Bcl-XL

Cancer Letters, 2008
Isothiocyanates are a class of phytochemicals able to induce apoptosis in numerous cells including Jurkat T-lymphoma cells overexpressing the oncoprotein Bcl-2. To test if isothiocyanates are also effective against other anti-apoptotic members of the Bcl-2 family we generated Jurkat cells stably overexpressing Bcl-X(L). Phenethyl isothiocyanate (PEITC)
Sarah L, Cuddihy, Kristin K, Brown, Susan J, Thomson, Mark B, Hampton   +3 more
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Phenethyl isothiocyanate sensitizes glioma cells to TRAIL-induced apoptosis

Biochemical and Biophysical Research Communications, 2014
Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) is a promising antitumor therapy. However, many cancer cells, including malignant glioma cells, tend to be resistant to TRAIL, highlighting the need for strategies to overcome TRAIL resistance. Here we show that in combination with phenethyl isothiocyanate (PEITC), exposure to TRAIL induced
Dae-Hee, Lee, Dong-Wook, Kim, Hai-Chon, Lee, Jung-Hyun, Lee, Tae-Hwa, Lee   +4 more
openaire   +2 more sources

ChemInform Abstract: Inhibition of Esophageal Tumorigenesis by Phenethyl Isothiocyanate

ChemInform, 1994
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
G. D. STONER, A. J. GALATI, C. J. SCHMIDT, M. A. MORSE   +3 more
openaire   +1 more source

Chemoprevention effect of phenethyl isothiocyanate

Toxicology, 2007
Nattaya Konsue, Costas Ioannides
openaire   +1 more source