Results 111 to 120 of about 517,508 (339)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

On parameter interpretability of phenomenological-based semiphysical models in biology

Informatics in Medicine Unlocked, 2019
Empirical and phenomenological-based models are used to represent biological and physiological processes. Phenomenological models are derived from the knowledge of the mechanisms that underlie the behavior of the system under study, while empirical ...
Laura Lema-Perez, Rafael Muñoz-Tamayo, Jose Garcia-Tirado, Hernan Alvarez   +3 more
doaj   +1 more source

Dynamics of Metastable Vacua in the Early Universe

, 1999
We study the question whether a possible metastable vacuum state is actually populated in a phase transition in the early universe, as is usually assumed in the discussion of vacuum stability bounds e.g. for Standard Model parameters. A phenomenological (
Alexander, Alford, Alford, Anderson, Arnold, Arnold, Bastian Bergerhoff, Bochkarev, Borrill, Boyanovsky, Espinosa, Gleiser, Gleiser, Grigorev, Krive, Lindner, Manfred Lindner, Manfred Weiser, Morikawa, Sher, Yamaguchi   +20 more
core   +2 more sources

Generalized Mechanism Model for Ecosystem Hysteresis

Advanced Science, EarlyView.
A simplified model examines ecosystem transitions into alternative states after disturbances by leveraging positive and negative feedbacks. It identifies critical tipping points and quantifies hysteresis. Tests conducted on lakes, grasslands, and pitcher‐plant leaves align closely with empirical data and enable the prediction of recovery trajectories ...
Yanbin Hao, Xin Wang, Jie Liu, Mingzi Wu, Jianqing Du, Kai Xue, Xiaoning Song, Xiaoyong Cui, Tong Zhao, Yanfen Wang   +9 more
wiley   +1 more source

Phenomenological Material Model of Foam Solids

Journal of Mechanical Engineering, 2015
In this contribution a new phenomenological model for pressure loaded foam materials is proposed. The presented relationship between compressive stresses and compressive strains is derived by using simple rheological models.
Goga V., Hučko B.
doaj   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

A Phenomenological Model for Estimating the Wear of Horizontally Straight Slurry Discharge Pipes: A Case Study

Lubricants
When a slurry TBM advances in pebble and rock strata, large rock particles are carried in pipelines out of a tunnel by moving slurry. To estimate the wear of horizontally straight slurry discharge pipes, a phenomenological model was proposed that was ...
Xinggao Li, Yidong Guo, Xingchun Li, Hongzhi Liu, Yi Yang, Yingran Fang   +5 more
doaj   +1 more source

Hump‐Shaped Relationship Between Microbial Carbon Use‐Efficiency and Soil Organic Carbon in Alpine Grasslands

Advanced Science, EarlyView.
On the Qinghai–Tibetan Plateau, microbial carbon use efficiency (CUE) peaks at intermediate soil organic carbon levels and declines thereafter. In carbon‐rich soils, the formation of stable mineral‐associated organic carbon is decoupled from microbial CUE.
Yuting Wang, Yongneng Wei, Gangsheng Wang, Yang Ruan, Ling Li, Xiang Liu, Yunfeng Yang, Qirong Shen, Ning Ling   +8 more
wiley   +1 more source

Wave‐Partition‐Governed Dual‐Site Spallation in Single Crystals

Advanced Science, EarlyView.
Crystalline anisotropy shapes shock‐wave propagation and the resulting damage evolution in single crystals. Large‐scale molecular dynamics and damage modeling uncover a dual‐spallation mechanism driven by anisotropic elasticplastic wave separation, which mitigates damage accumulation.
Youlin Zhu, Sheng Qian, Lianfu Qiu, Jianian Hu, Guoqiang Luo, Qiang Shen, Qi Tong   +6 more
wiley   +1 more source

The phenomenological model of depression: from methodological challenges to clinical advancements. [PDF]

Front Psychol, 2023
Frohn OO, Martiny KM.
europepmc   +1 more source