Results 61 to 70 of about 516,324 (301)
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen +7 more
wiley +1 more source
THE CATEGORY OF "MUNDANE CONSCIOUSNESS" IN PSYCHOLOGY
Вестник Кемеровского государственного университета, 2017 The article analyzes the phenomenon of ordinary consciousness as a category, whose largely contradictory and paradoxical nature evokes interest.
N. P. Andryushkova
doaj +1 more source
Психолого-педагогические исследования, 2023 The paper presents the results of studying the activities of technology clubs operating in different regions of Russia. Based on the materials of the All-Russian competition of technological clubs, the objectives, content and forms of ...
Y.V. Gromyko, A.A. Ustilovskaya,
doaj +1 more source
Mamardashvili, an Observer of the Totality. About “Symbol and Consciousness”, and the cross between East and West, infinity and finiteness. . . [PDF]
, 2018 The paper discusses a few tensions “crucifying” the works and even personality of the great Georgian philosopher Merab Mamardashvili: East and West; human being and thought, symbol and consciousness, infinity and finiteness, similarity and differences ...
Penchev, Vasil
core
A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Subtotal hippocampal resection can leave residual hippocampal tissue, yet the immediate postoperative electrophysiologic evolution of such remnants is unknown. We describe a patient with drug‐resistant temporal lobe epilepsy in whom a hippocampal remnant was continuously monitored using a responsive neurostimulator (RNS) following subtotal ...
Patrick Hartnett +5 more
wiley +1 more source
Darwin's Rainbow: Evolutionary radiation and the spectrum of consciousness [PDF]
, 2006 Evolution is littered with paraphyletic convergences: many roads lead to functional Romes. We propose here another example - an equivalence class structure factoring the broad realm of possible realizations of the Baars Global Workspace consciousness ...
Wallace, Robert G., Wallace, Rodrick
core
Transgressive consciousness as cultural and historical phenomenon [PDF]
Vestnik of Saint Petersburg State University of Culture, 2017 The concept of the ultimate bases of culture is investigated. Specifi cs of transgressive consciousness as a cultural and historical phenomenon are revealed. The inadequacy of the reduction of the transgressive experience to the act of transgression is substantiated.
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos +9 more
wiley +1 more source