Results 31 to 40 of about 9,159 (181)

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

open access: yesAdvanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed   +15 more
wiley   +1 more source

Midgut bacteria in deltamethrin-resistant, deltamethrin-susceptible, and field-caught populations of Plutella xylostella, and phenomics of the predominant midgut bacterium Enterococcus mundtii

open access: yesScientific Reports, 2017
Gut bacteria play a significant role in host insect. This study evaluated detail difference of midgut bacteria in deltamethrin-resistant, deltamethrin-susceptible and field-caught populations of diamondback moth, and studied phenomics of the predominant ...
Wenhong Li   +3 more
doaj   +1 more source

Bromodomain Protein BRD4 Accelerates Glucocorticoid Dysregulation of Bone Mass and Marrow Adiposis by Modulating H3K9 and Foxp1

open access: yesCells, 2020
Glucocorticoid provokes bone mass loss and fatty marrow, accelerating osteoporosis development. Bromodomain protein BRD4, an acetyl–histone-binding chromatin reader, regulates stem cell and tissue homeostasis.
Feng-Sheng Wang   +9 more
doaj   +1 more source

Precision Mapping of Retinal Disease: Identification of Differential Progression Trajectories via Imaging Phenomics

open access: yesiMetaMed, EarlyView.
Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson   +11 more
wiley   +1 more source

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture‐Induced Sepsis and the Ameliorating Effects of Adipose‐Derived Stem Cell Exosomes

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Shao‐Chun Wu   +5 more
wiley   +1 more source

Breeding for multi‐stress resilience in crops: Myth or possibility?

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Climate change threatens millions of farmers worldwide by exposing crops to multiple concurrent or sequential environmental stresses such as drought, heat, waterlogging, and diseases. Although crops have long been selected under naturally occurring multi‐stress conditions, breeding pipelines largely focus on optimal or single‐stress environments ...
Hamid Khazaei   +2 more
wiley   +1 more source

Non-destructive, high-content analysis of wheat grain traits using X-ray micro computed tomography

open access: yesPlant Methods, 2017
Background Wheat is one of the most widely grown crop in temperate climates for food and animal feed. In order to meet the demands of the predicted population increase in an ever-changing climate, wheat production needs to dramatically increase.
Nathan Hughes   +7 more
doaj   +1 more source

Crop Seed Phenomics: Focus on Non-Destructive Functional Trait Phenotyping Methods and Applications

open access: yesPlants, 2023
Seeds play a critical role in ensuring food security for the earth’s 8 billion people. There is great biodiversity in plant seed content traits worldwide.
Gokhan Hacisalihoglu, Paul Armstrong
doaj   +1 more source

A national crop wild relative checklist for Zimbabwe reveals edible crop wild relative diversity of regional and global importance

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Crop wild relatives (CWR) in Zimbabwe are reservoirs of beneficial agronomic traits, yet they remain under‐documented and poorly conserved. This study developed Zimbabwe's first national CWR checklist based on a conceptual framework combining floristic, ecological and ethnobotanical data, revealing over 2700 taxa, with nearly 1000 edible species ...
Kudakwashe Mutasa   +3 more
wiley   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá   +1 more
wiley   +1 more source

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