Results 191 to 200 of about 3,800,975 (380)

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.

Immunity, 2017
S. Krasemann, C. Madore, R. Cialic, Caroline Baufeld, Narghes Calcagno, Rachid El Fatimy, L. Beckers, E. O’Loughlin, Yang Xu, Zain Fanek, David J. Greco, Scott t. Smith, G. Tweet, Zachary Humulock, T. Zrzavy, Patricia Conde-Sanroman, Mar Gacias, Z. Weng, Hao Chen, Emily C. Tjon, F. Mazaheri, K. Hartmann, A. Madi, J. Ulrich, M. Glatzel, A. Worthmann, J. Heeren, B. Budnik, C. Lemere, T. Ikezu, F. Heppner, V. Litvak, D. Holtzman, H. Lassmann, H. Weiner, J. Ochando, C. Haass, O. Butovsky   +37 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Revealing the clinical phenotype of atypical neuronal ceroid lipofuscinosis type 2 disease: Insights from the largest cohort in the world [PDF]

, 2020
Charles Marques Lourenço, André Luiz Santos Pessoa, Carmen Curiati Mendes, Carolina Rivera‐Nieto, Diane Vergara, M. Troncoso, Emily Gardner, Francisca Mallorens, Lina Marcela Tavera, Luis Arturo Lizcano, Nora Atanacio, Norberto Guelbert, Norma Spécola, Nury Mancilla, Carolina Fischinger Moura de Souza, Sara Mole   +15 more
openalex   +1 more source

Validation of a computational phenotype for finding patients eligible for genetic testing for pathogenic PTEN variants across three centers [PDF]

, 2022
Cartik R. Kothari, Siddharth Srivastava, Youssef A. Kousa, Rima Izem, Marcin Gierdalski, Dong‐Kyu Kim, Amy B. Good, Kira A. Dies, Gregory Geisel, Hiroki Morizono, Vittorio Gallo, Scott L. Pomeroy, Gwenn A. Garden, Lisa M. Guay‐Woodford, Mustafa Şahin, Paul Avillach   +15 more
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion [PDF]

, 2017
Guangxin Li, Lingfeng Qin, Lei Wang, Xuan Li, Alexander W. Caulk, Jian Zhang, Pei‐Yu Chen, Shijie Xin   +7 more
openalex   +1 more source

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

Nature Reviews. Cancer, 2007
H. Peinado, David Olmeda, A. Cano
semanticscholar   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Route of Adenovirus-Based HIV-1 Vaccine Delivery Impacts the Phenotype and Trafficking of Vaccine-Elicited CD8 ⁺ T Lymphocytes

, 2010
David R. Kaufman, Maytal Bivas‐Benita, Nathaniel L. Simmons, Darby D. Miller, Dan H. Barouch   +4 more
openalex   +1 more source