Results 221 to 230 of about 3,800,975 (380)

The thrifty phenotype hypothesis.

British Medical Bulletin, 2001
Nicholas Hales, David J P Barker, C N Hales   +2 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

PhenoFit: a framework for determining computable phenotyping algorithm fitness for purpose and reuse. [PDF]

J Am Med Inform Assoc
Wiley LK, Rasmussen LV, Levinson RT, Malinowski J, Manemann SM, Wilson MP, Chapman M, Pacheco JA, Walunas TL, Starren JB, Bielinski SJ, Richesson RL.   +11 more
europepmc   +1 more source

Characterizing cardiac phenotype in Friedreich's ataxia: The CARFA study

, 2021
L. Legrand, Jonathan W. Weinsaft, Françoise Pousset, Claire Ewenczyk, Perrine Charles, Stéphane Hatem, Anna Heinzmann, Marie Biet, Alexandra Dürr, Alban Redheuil   +9 more
openalex   +2 more sources

CpG island methylator phenotype in colorectal cancer.

Proceedings of the National Academy of Sciences of the United States of America, 1999
M. Toyota, N. Ahuja, Mutsumi Ohe-Toyota, J. Herman, S. Baylin, J. Issa   +5 more
semanticscholar   +1 more source

Phenotype matters [PDF]

Nature Genetics, 2004
openaire   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Editorial: Difficult and Severe Asthma in Children

Frontiers in Pediatrics, 2019
Andrew Bush, Andrew Bush, Andrew Bush, Renato Cutrera, Giorgio Piacentini, Francesca Santamaria, Nicola Ullmann   +6 more
doaj   +1 more source

Extending the Use of Mendelian Randomisation With Non-Inherited Variants to Assess Socially Transmitted Parental Exposures Under Assortative Mating. [PDF]

Genet Epidemiol
Woolf B, Mason A, Shapland CY, Kang H, Sallis HM, Burgess S, Munafò MR.   +6 more
europepmc   +1 more source

Using multiple regression, Bayesian networks and artificial neural networks for prediction of total egg production in European quails based on earlier expressed phenotypes

, 2015
V.P.S. Felipe, Martinho A. Silva, B.D. Valente, Guilherme J. M. Rosa   +3 more
openalex   +1 more source