Results 241 to 250 of about 2,545,958 (345)

Ly phenotype of cytotoxic T cells for syngeneic tumor. [PDF]

, 1976
Hiroshi Shiku, Takahiro Takahashi, Michael A. Bean, L J Old, Herbert F. Oettgen   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Think classical homocystinuria if the genetic test did not confirm Marfan syndrome: Late diagnosis and phenotypic variability in adult siblings with classical homocystinuria. [PDF]

Mol Genet Metab Rep
Sultan R, Urlacher J, Athey T, Kannu P, Seres P, Mercimek-Andrews S.   +5 more
europepmc   +1 more source

Defective transport and other phenotypes of a periplasmic "leaky" mutant of Escherichia coli K-12

, 1979
James J. Anderson, James M. Wilson, Dale L. Oxender   +2 more
openalex   +1 more source

Simultaneous analysis of dapsone and monoacetyldapsone employing high performance liquid chromatography: a rapid method for determination of acetylator phenotype. [PDF]

, 1978
K. Carr, J A Oates, AS Nies, Raymond L. Woosley   +3 more
openalex   +1 more source

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

Nature Cell Biology, 2015
Rémi-Martin Laberge, Yu Sun, Arturo V. Orjalo, C. Patil, Adam Freund, Li-li Zhou, Samuel C. Curran, Albert R. Davalos, Kathleen A. Wilson-Edell, Su Liu, Chandani Limbad, M. Demaria, P. Li, G. Hubbard, Y. Ikeno, M. Javors, P. Desprez, C. Benz, P. Kapahi, P. Nelson, J. Campisi   +20 more
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Identification of diabetes related phenotype and diagnostic biomarkers in coronary artery disease. [PDF]

PeerJ
Aihemaiti G, Abula A, Luo J, Zhao Q, Song N, Liu F, Adili N, Yang Y, Li X.   +8 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

New variants and genotype-phenotype correlation in <i>KIF5A</i> mutation: the contribution of a large Italian cohort. [PDF]

J Med Genet
Ferese R, Suppa A, Campopiano R, Scala S, Sammarone F, Di Pilla L, Di Pardo A, Chiaravalloti MA, Griguoli AM, Cannella M, D'Alessio C, Storto M, Fanelli M, Zampogna A, Patera M, Inghilleri M, Ceccanti M, Cambieri C, Buttari F, Peconi C, Giardina E, Zampatti S, Centonze D, Gambardella S.   +23 more
europepmc   +1 more source