Results 251 to 260 of about 2,545,958 (345)

Age‐Related Changes in Myeloid Cells and Their Impact on Subcutaneous Melanoma Growth in Mice

Aging and Cancer, EarlyView.
Our findings reveal that age‐related changes in subcutaneous melanoma growth and immunotherapy response are context‐dependent. In models where tumor growth and treatment resistance increase with age, this effect is partly driven by enhanced immunosuppression from myeloperoxidase‐active Gr‐1⁺ myeloid cells.
Kaitlyn M. Landreth, Dylan D. Thomas, Remi Nohoesu, Angisha Basnet, F. Heath Damron, Mary Garland‐Kledzik, Emel Sen Kilic, Tracy W. Liu   +7 more
wiley   +1 more source

Heterogeneity phenotypes in recurrent glioblastoma: a multimodal MRI-based spatial mapping framework for precision treatment. [PDF]

BMC Med Imaging
Zhu Y, Huang D, Ji Y, Wang R, Li Y, Xu Y, Zhuang Y, Liu Z, Li Y, Wang W.   +9 more
europepmc   +1 more source

Metabolomics activity screening for identifying metabolites that modulate phenotype

Nature Biotechnology, 2018
Carlos Guijas, J. R. Montenegro-Burke, Benedikt Warth, Benedikt Warth, M. Spilker, G. Siuzdak   +5 more
semanticscholar   +1 more source

The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey, Ahmad A. Toubasi, Jiacheng Wang, Habeeb F. Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A. Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato   +17 more
wiley   +1 more source

Clinical and Biochemical Characterization of Fabry Disease Associated GLA Gene Variants: Data From a Large Cohort of 469 Thousand Genotyped Subjects of the UK Biobank Database. [PDF]

J Inherit Metab Dis
Giammanco A, Gagliardo CM, Scrimali C, Brucato F, Fasciana TMG, Averna M, Cefalu AB, Noto D.   +7 more
europepmc   +1 more source

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Limited effects of non-steroidal anti-inflammatory drugs (NSAIDs) on imaging outcomes in osteoarthritis: observational data from the osteoarthritis initiative (OAI). [PDF]

BMC Musculoskelet Disord
Kreutzinger V, Ziegeler K, Luitjens J, Joseph GB, Lynch J, Lane NE, McCulloch CE, Nevitt M, Link TM.   +8 more
europepmc   +1 more source

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap

Circulation, 2016
Sanjiv J. Shah, D. Kitzman, B. Borlaug, L. van Heerebeek, M. Zile, D. Kass, W. Paulus   +6 more
semanticscholar   +1 more source

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source

Phenotyping Chronic Pain and Neuropathic Pain in Population Studies. [PDF]

Eur J Pain
Liang IJ, Senaratne DNS, Smith BH.
europepmc   +1 more source