Results 271 to 280 of about 2,909,871 (334)

Wanted: A population genetic theory of biological noise regulation. [PDF]

PLoS Genet
Weinreich DM, Sgouros T, Raynes Y, Burtsev H, Chang E, Rajakumar S, Bravo IG, Petak C.   +7 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Inflammatory phenotype drives different immunosuppressive response in COPD exacerbations. [PDF]

BMC Pulm Med
Miralles C, Miñana MD, Nieto ML, Del Carmen Aguar M, Domínguez-Márquez V, Soler-Cataluña JJ.   +5 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Physiologic phenotypes in blunt thoracic aortic injury: implications for risk stratification and surgical decision-making using machine learning. [PDF]

Front Digit Health
Jenkins PD, Kolesnikov MR, Willis S, Andujo V, Lian T, Thanawala R, Bhamidipati C, Regner J, Doberne J.   +8 more
europepmc   +1 more source

Novel TSPAN12 mutations in patients with familial exudative vitreoretinopathy and their associated phenotypes.

, 2011
Huiqin Yang, Xueshan Xiao, Shiqiang Li, Guiying Mai, Qingjiong Zhang   +4 more
openalex   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Artificial intelligence-based clustering to identify functional risk phenotypes in heart failure. [PDF]

Open Heart
Qiu X, Ma J, Xu L, Jiang M, Pu J.
europepmc   +1 more source

The role of alpha-thalassemia in sickle cell disease phenotype in Angolan pediatric patients

, 2020
Miguel Brito, Brígida Santos, Mariana Delgadinho, Joana Ferreira, Ilda Jeremias, Miguel Panzo, Lucas Catumbela, Graciete salvador, Isabel Valentim, Félix Zagi, Fátima Silva, Isabel Germano, Armandina Miranda, Ana Paula Arez, Paula Faustino   +14 more
openalex   +1 more source