Results 101 to 110 of about 1,424,637 (273)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Development of a phenotypic screening assay to measure activation of cancer-associated fibroblasts
Frontiers in PharmacologyBackgroundIn cancer metastasis, tumor cells condition distant tissues to create a supportive environment, or metastatic niche, by driving the activation of cancer-associated fibroblasts (CAFs).
Marcus M. Ilg +6 more
doaj +1 more source
Genetic and Biologic Characterization of Some Olive (O/ea europaea L.) Cultivars Grown in Turkey
Journal of Agricultural Sciences, 2004 There are many olive (O/ea europaea L.) varieties grown in Anatolia, vvhich have not been characterized (morphologic and biologic characteristics), yet. Some of them that have been identified by morphologic and biological characteristics, but stili have ...
Mücahit Taha Ozkaya
doaj +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Frontiers in GeneticsObjectiveThis study investigates the role of miR-18a-5p in the phenotypic transformation of airway smooth muscle cells (ASMCs) and its underlying mechanism in asthma-related airway remodeling.MethodsExpression of miR-18a-5p in sputum from asthma patients
Lijuan Hu, Lei Li
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Infection and Drug Resistance, 2021 Tsegaye Alemayehu,1 Solomon Asnake,1 Bereket Tadesse,2 Elshaday Azerefegn,2 Enkosilassie Mitiku,2 Asnakech Agegnehu,2 Netsanet Nigussie,2 Techilo H/Mariam,2 Moges Desta1 1Hawassa University College of Medicine and Health Science, School of Medical ...
Alemayehu T +8 more
doaj
Majalah Kedokteran Bandung, 2015 The presence of the P. falciparum resistance and decreased of efficacy against artemisinin and its derivatives result in increasingly complex malaria issues.
Lilik Maslachah +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source