Results 121 to 130 of about 1,424,637 (273)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Probiotic and Postbiotic Potentials of Enterococcus faecalis EF-2001: A Safety Assessment
PharmaceuticalsBackground: Probiotics, which are live microorganisms that, when given in sufficient quantities, promote the host’s health, have drawn a lot of interest for their ability to enhance gut health. Enterococcus faecalis, a member of the human gut microbiota,
Kwon Il Han +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Eye of the Chiropterologist: Phenotypic Versus Genotypic Identification of Bats
Ecology and EvolutionBats are a diverse and ecologically important group of mammals that play critical roles in ecosystems. Accurate identification is necessary to comprehend bat species' ecology and behavior to further the conservation of bats. Both phenotypic and genotypic
F. D. Dami +14 more
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Sensors for Antibiotics Susceptibility Testing—Recent Advances
Advanced Sensor ResearchThe age of antibiotics, which began with the discovery of penicillin in 1929, marks an important period in medical history, as deadly bacterial infections seemed to be a thing of the past.
Oliver Riester +3 more
doaj +1 more source
Physicocytological Invigoration of Root Meristematic Chromosomal Anomalies of Celosia argentia L. by the Genetic Potential Stress Inflence of Water Hyacinth Deproteinized Foliage Whey [PDF]
Journal of Stress Physiology & Biochemistry, 2018 In earlier studies, high concentration of DPJ from various forages inhibited germination, induced mutations in some seedlings and caused phytotoxic phenotypical changes in plants during growth.
Rajesh Khanduji Jadhav
doaj