Results 71 to 80 of about 1,110,066 (310)
Current Opinion in Hematology, 2012 Although recorded evidence of phenotyping bleeding disorders extends back two millennia, standardization of phenotyping has only begun in the past half century. This was spurred by the need for greater precision in diagnosing disorders in order to select proper laboratory tests and treatment, and the realization that the bleeding history provides ...
Paula, James, Barry S, Coller
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Moreno et al 2019 phenotypic plasticity JAVBIO
, 2019 Dataset of the scientific article "Phenotypic plasticity in breeding plumage signals in both sexes of a migratory bird: responses to breeding conditions".Peer ...
Moreno Klemming, Juan +3 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The role of phenotypic plasticity in the colonization of novel environments [PDF]
, 2013 Biological invasions have been argued to be facilitated by phenotypic plasticity. Although experiments have shown plasticity can be adaptive, our current understanding is limited to comparative studies that measure plasticity between invasive and non ...
NC DOCKS at The University of North Carolina at Greensboro +1 more
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Phenotypic screening in the 21st century [PDF]
, 2015 In the genomic era of 1990s-2000s, pharmaceutical research moved to target-based drug discovery which enabled development of a number of small molecule drugs against a wide range of diseases.
Priest, Birgit T. +3 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
InsectsBeekeepers use a variety of methods to control Varroa destructor (varroa). Chemical control relies heavily on flumethrin, amitraz, coumaphos, and tau-fluvalinate products.
Ali Sorucu +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Integrated Phenotype [PDF]
Integrative and Comparative Biology, 2012 Proper functioning of complex phenotypes requires that multiple traits work together. Examination of relationships among traits within and between complex characters and how they interact to function as a whole organism is critical to advancing our understanding of evolutionary developmental plasticity.
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