Results 211 to 220 of about 173,452,781 (258)

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Genome-Wide Association Study of Body Conformation and Carcass Composition Traits in Landrace Pigs. [PDF]

Animals (Basel)
Deng S, Ruan D, Pu Z, Cao Z, Huang L, Lin M, Wu JJ, Zheng E, Yang J, Liu L, Zhang H.   +10 more
europepmc   +1 more source

Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
IGF2BP1 promotes gemcitabine resistance in pancreatic cancer by stabilizing m6A‐modified FTH1 transcripts and protecting them in stress granules, thereby suppressing ferroptosis. Pharmacological inhibition of IGF2BP1 disrupts this protective pathway, restores ferroptotic sensitivity, and enhances gemcitabine efficacy in resistant tumors.
Ying‐Qin Zhu, Yue Huang, Jing‐Yuan Ye, Si‐Yuan Lu, Zhi‐De Liu, Ming‐Jian Ma, De‐Liang Fang, Zi‐Yi Zhao, Jin‐Zhao Xie, Jiao Chen, Xiao‐Yu Yin   +10 more
wiley   +1 more source

An Integrated Framework Coupling Hierarchical Hyperspectral i-trait Screening, Gene Identification, and Functional Validation for Genetic Dissection of Salt Tolerance in Cotton. [PDF]

Adv Sci (Weinh)
Xu B, Liu L, Yu M, Guo Y, Ye J, Zhang J, Zhao R, Yang J, Yang W, Xu Y, Fan L, Yang Z.   +11 more
europepmc   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

Phenotypic Variability of Wool Traits in the Gentile di Puglia Sheep Breed: Implications for Conservation and Sustainable Management. [PDF]

Animals (Basel)
Molina MG, Bramante G, Pierini C, Saleh MS, D'Onghia A, Grande S, Mangini G, Bruno S, Devoto V, Ciani E, Sarti FM, De Palo P, Landi V.   +12 more
europepmc   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Transgressive Segregation, Reciprocal Effects and Multi-Trait Selection in an F2 Bread Wheat Diallel Under Speed Breeding. [PDF]

Plants (Basel)
Yorulmaz L, Rufaioğlu SB, Tunç M, İpekeşen S, Okur M, Biçer BT, Akıncı C.   +6 more
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

Phenotypic characterization and resilience assessment of wheat genotypes under single and combined abiotic stresses. [PDF]

Front Plant Sci
Sun L, Niu L, Shi X, Jiao B, Ma C, Yang F, Dong F, Zhou S.   +7 more
europepmc   +1 more source