Results 131 to 140 of about 216,179 (302)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Diversity of Molecular Phenotypes in Acute Leukemias

, 1989
Recent advances in immunological studies of human leukemias have enabled us to address the lineage of leukemic cells. More recent molecular studies of leukemic cells have made it possible to study the regulation of genes encoding antigen receptors, indicating there is differentiation-linked rearrangement of the receptor genes with lymphoid leukemias ...
S, Mizutani, K, Nakamura, M, Ozaki, C, Tamura, M, Sasaki, Y, Tsunematsu, J, Fujimoto, J, Hata, N, Kobayashi   +8 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Phenotypic diversity for agro-morphological traits in pigeon pea landraces [(Cajanus cajan L.) Millsp.] cultivated in southern Benin

Open Agriculture, 2019
Pigeon pea is an important but unfortunately neglected grain legume crop in Benin. In this study, the phenotypic diversity in 84 landraces from Benin and four advanced varieties were evaluated at two locations during two consecutive rainy seasons. Twelve
Zavinon Fiacre, Adoukonou-Sagbadja Hubert, Bossikponnon Angelo, Dossa Hermann, Ahanhanzo Corneille   +4 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

GENETIC PARAMETERS OF RED GINGER ACCESSIONS (Zingiber officinale var. rubrum) FROM JAVA ISLAND

Jurnal Agrotek Tropika
Red ginger is spicier than other types of ginger, with benefits in the pharmaceutical industry. Limited red ginger seeds are the main problem in red ginger cultivation.
Eka Oktaviani, Agleri Rante, Agus Suroto
doaj  

Genetic diversity of Rhododendron dauricum based on morphological traits and SSR markers

Frontiers in Plant Science
Rhododendron dauricum L. is one of the most important ornamental plants in Northeast China for its beautiful flowers. Wild R. dauricum populations are mainly distributed in Greater and Lesser Khingan Mountains in Heilongjiang, China.
Dan Wang, Ying Ma, Xueli Zhao, Ling Wang
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Multivariate analysis reveals phenotypic diversity of Euscaphis japonica population.

, 2019
Fruit traits affect population genetic diversity by affecting seed protection and dispersal strategies, thereby comprising important components of phenotypic variation.
Shuang-Quan Zou, Xueyan Yuan, Weihong Sun, Siren Lan, Zhong-Jian Liu, Wen-Chieh Tsai   +5 more
core   +1 more source