Results 51 to 60 of about 216,179 (302)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Divergence, Convergence and Phenotypic Diversity of Neotropical Frugivorous Bats

, 2018
Knowing how adaptation shapes morphological evolution is fundamental to understanding the processes that promote biological diversity. However, there is a lack of empirical evidence on the effects of adaptive radiations on phenotypic diversity, which is ...
Maria E. De la vega, Maria E. De la vega, Oscar E. Murillo-García, Oscar E. Murillo-García   +3 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

How might epigenetics contribute to ecological speciation? [PDF]

, 2013
Speciation research has seen a renewed interest in ecological speciation, which emphasises divergent ecological selection leading to the evolution of reproductive isolation.
Ritchie, Michael G., Smith, Gilbert
core  

Phenotypic diversity in the Ethiopian noug germplasm

, 2000
Noug (Guizotia abyssinica (L.f.) Cass.: 2n = 30), a member of the Compositae family, is grown as an oilseed crop in Ethiopia. The crop grows best on poorly drained heavy clay soils.
Tsige Genet, Ketema Belete, Genet, Tsige, Belete, Ketema   +3 more
core   +3 more sources

Use of easy measurable phenotypic traits as a complementary approach to evaluate the population structure and diversity in a high heterozygous panel of tetraploid clones and cultivars

BMC Genetics, 2018
Background Diversity in crops is fundamental for plant breeding efforts. An accurate assessment of genetic diversity, using molecular markers, such as single nucleotide polymorphism (SNP), must be able to reveal the structure of the population under ...
Martin E. Tagliotti, Sofia I. Deperi, Maria C. Bedogni, Ruofang Zhang, Norma C. Manrique Carpintero, Joseph Coombs, David Douches, Marcelo A. Huarte   +7 more
doaj   +1 more source

Phenotypic Diversity of 15q11.2 BP1–BP2 Deletion in Three Korean Families with Development Delay and/or Intellectual Disability: A Case Series and Literature Review

Diagnostics, 2021
The 15q11.2 breakpoint (BP) 1–BP2 deletion syndrome is emerging as the most frequent pathogenic copy number variation in humans related to neurodevelopmental diseases, with changes in cognition, behavior, and brain morphology.
Ji Yoon Han, Joonhong Park
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Integrating phenotypic and genetic diversity, and species distribution modeling to set long-term conservation strategies for the endangered Afzelia africana in Benin (West Africa)

Trees, Forests and People
Afzelia africana is one of the most threatened multipurpose species in sub-Saharan Africa. Understanding its potentially suitable habitats, coupled with its phenotypic and genetic diversity is valuable for establishing sustainable and efficient ...
Dowo Michée Adjacou, Rodrigue Idohou, Alain Sèakpo Yaoitcha, Jacques Kadjobgé Idohou Ayena, Thierry Dehouegnon Houehanou, Gérard Nounagnon Gouwakinnou   +5 more
doaj   +1 more source