Results 241 to 250 of about 1,113,115 (292)

Mapping phenotypic heterogeneity and cardiometabolic risk in obesity using a tree-based dimensionality reduction framework. [PDF]

J Transl Med
Zhao Y, Wang W, Wang Z, Ma J, Zhang J, Shao J, Zhou K, Pan Q, Nie Z, Xu G, Guo L.   +10 more
europepmc   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Microglia's Phenotypic Heterogeneity in Pain Pathogenesis and Electroacupuncture Analgesia: Mechanisms and Therapeutic Potential. [PDF]

J Pain Res
Ji D, Lyu Z, Erasmus S, Wu Y, Li X, Chen X, Fang J, Du J, Fang J, Zhou J, Liang Y.   +10 more
europepmc   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction. [PDF]

Circulation
Packer M, Schiattarella GG, Petrie MC, Burkhoff D, Butler J, Lam CSP, Zannad F, Vaduganathan M, Borlaug BA.   +8 more
europepmc   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

From a novel pathogenic SAMD9L variant to cohort-wide insights: Whole-genome sequencing highlights somatic genetic rescue and phenotypic heterogeneity. [PDF]

Br J Haematol
Dellal H, Klifa R, Larcher L, Passet M, Celse T, Gouas L, Tusseau M, AURAGEN Consortium, Praga A, Bernard V, Fusaro M.   +10 more
europepmc   +1 more source

Regulation of ribosome hibernation controls <i>Legionella</i> survival, infection, antibiotic tolerance, and phenotypic heterogeneity. [PDF]

mBio
Schmid C, Trinkler SN, Vittori ET, Oborská-Oplová M, Panse VG, Hilbi H.   +5 more
europepmc   +1 more source

Phenotypic heterogeneity in adenomyosis: internal and external subtypes. [PDF]

Arch Gynecol Obstet
Liang Y, Zhu M, Sun F, Liu X, Liu J, Zhang J.   +5 more
europepmc   +1 more source