Results 311 to 320 of about 832,396 (367)

How a Melanism Mutant Responds to Different Temperatures: A Case Study in Ladybird Beetle <i>Harmonia axyridis</i> Demonstrating Thermal-Induced Phenotypic Plasticity. [PDF]

Ecol Evol
Sun YX, Zhang CL, Wang SS, Ma RY, Li XW, Hao YN, Kong WN.   +6 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

ID8 cells manifest phenotypic plasticity and molecular heterogeneity of high-grade serous ovarian cancer in response to the local tissue niche. [PDF]

Sci Rep
Gupta R, Shravan S, Agwane SB, Bankar RM, Bapat SA.   +4 more
europepmc   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Wild rice-associated <i>Vibrio</i> promotes plant growth and exhibits genomic and phenotypic plasticity for plant adaptations. [PDF]

mSystems
Kulanthaivel K, Rameshkumar N.
europepmc   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source

Notch3 regulates pericyte phenotypic plasticity in colorectal cancer

Chalkidi N, Stavropoulou A, Arvaniti V, Paraskeva C, Monogyiou A, Sakkou M, Nikolaou C, Koliaraki V.   +7 more
europepmc   +1 more source

Genotypic responses to different environments and reduced precipitation reveal signals of local adaptation and phenotypic plasticity in woodland strawberry. [PDF]

Ann Bot
De-la-Cruz IM, Batsleer F, Bonte D, Diller C, Hytönen T, Luis Izquierdo J, Osorio S, Posé D, de la Rosa A, Vandegehuchte ML, Muola A, Stenberg JA.   +11 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

On the evolutionary origin of discrete phenotypic plasticity. [PDF]

G3 (Bethesda)
Sakamoto T, Innan H.
europepmc   +1 more source