Results 331 to 340 of about 832,396 (367)

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2‐Mediated Cytoskeletal‐Nuclear Mechanotransduction

Advanced Science, EarlyView.
Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen, Xinhui Zheng, Jieliu Li, Minyu He, Dongqi Fan, Xingyu Zhu, Qiming Zhai, Liangjing Xin, Tao Chen   +8 more
wiley   +1 more source

Light-induced epigenetic modifications in the hypothalamus during avian embryonic development enhance phenotypic plasticity. [PDF]

Front Cell Dev Biol
Bartman J, Rosenberg T, Parnas H, Yosofov R, Avital-Cohen N, Weiss R, Harmatz G, Rozenboim I, Marco A.   +8 more
europepmc   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer. [PDF]

Nat Genet
Mzoughi S, Schwarz M, Wang X, Demircioglu D, Ulukaya G, Mohammed K, Zorgati H, Torre D, Tomalin LE, Di Tullio F, Company C, Dramaretska Y, Leushacke M, Giotti B, Lannagan TR, Lozano-Ojalvo D, Karras P, Vermeulen PB, Hasson D, Sebra R, Tsankov AM, Sansom OJ, Marine JC, Barker N, Gargiulo G, Guccione E.   +25 more
europepmc   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor-adapted non-small cell lung cancer cell lines. [PDF]

FEBS Open Bio
Nanthaprakash TV, Gourlay CW, Oehme I, Garrett MD, Cinatl J, Wass MN, Michaelis M.   +6 more
europepmc   +1 more source

STIM1 signaling modulates invasive phenotypic plasticity by regulating calpain-dependent cleavage of integrin-β4 in nasopharyngeal carcinoma cells. [PDF]

Cancer Cell Int
Deng W, Huang W, Huang Y, Huang L, Ye L, Liu F, Li M, Weng J, He Q, Zhang J, Qu S, Wei J.   +11 more
europepmc   +1 more source

Meta-analysis reveals that phenotypic plasticity and divergent selection promote reproductive isolation during incipient speciation. [PDF]

Nat Ecol Evol
Jarrett BJM, Downing PA, Svensson EI.
europepmc   +1 more source

Phenotypic plasticity in bacterial elongation among closely related species

Delaby M, Yang L, Jacq M, Gallagher KA, Kysela DT, Hughes V, Pulido F, Veyrier FJ, VanNieuwenhze MS, Brun YV.   +9 more
europepmc   +1 more source

Phenotypic plasticity during metastatic colonization.

Trends in Cell Biology, 2022
Most solid cancer-related deaths result from metastasis, a multistep process in which cancer cells exit the primary site, intravasate into the bloodstream, extravasate, and colonize distant organs. Colonization is facilitated by clonal selection and the high phenotypic plasticity of cancer cells that creates reversible switching of cellular states ...
Charly Jehanno, Milica Vulin, Veronica Richina, Federica Richina, M. Bentires‐Alj   +4 more
semanticscholar   +3 more sources