Results 131 to 140 of about 2,617,089 (305)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Phenotypic variation of the seed oil and protein contents in the 369 accessions under 5 environments.

, 2014
Phenotypic variation of the seed oil and protein contents in the 369 accessions under 5 environments.
Libin Wei (414072), Tide Zhang (621253), Xiuhua Han (621254), Hongmei Miao (414071), Haiyang Zhang (132530), Chun Li (57810)   +5 more
core   +1 more source

Time related behaviour of phenotypic variation in Lotus corniculatus regenerated under field conditions.

, 1985
Time related behaviour of phenotypic variation in Lotus corniculatus regenerated under field ...
Arcioni S., Damiani F., PEZZOTTI, Mario, Mariotti D.   +3 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Geographical variation and genetic diversity of Parashorea chinensis germplasm resources

Frontiers in Plant Science
IntroductionParashorea chinensis is a rare monodominant species in southwest China known for its production of high-quality timber, is facing decline due to its narrow distribution, human interference and habitat destruction.
Yuanyuan Xu, Yuanyuan Xu, Shinan Liu, Shinan Liu, Patrick M. Finnegan, Fang Liu, Izhar Ali, Izhar Ali, Haidong Zhang, Haidong Zhang, Mei Yang, Mei Yang   +11 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

RRphylo: a new method for testing evolutionary rate variation and shifts in phenotypic evolution

, 2017
<p>A new method for testing evolutionary rate variation and shifts in phenotypic evolution</p ...
Melchionna, Marina, Melchionna, M (8199270), Mondanaro, Alessandro, Carmela Serio, Castiglione, Silvia, Marina Melchionna, Martina Piccolo, Piccolo, M, Piccolo, M (8199267), Mondanaro, A (8199273), Melchionna, M, Di Febbraro, M (8199279), Mirko Di Febbraro, Serio, Carmela, Silvia Castiglione, Castiglione, S (8199261), Raia, Pasquale, Castiglione, S, Raia, P (8199282), Raia, P, Gianmarco Tesone, Tesone, G (8199264), Piccolo, Martina, Tesone, G, Alessandro Mondanaro, Serio, C, Di Febbraro, Mirko, Mondanaro, A, Pasquale Raia, Serio, C (8199276), Di Febbraro, M, Tesone, Gianmarco, Melchionna Marina, Mondanaro Alessandro, Serio Carmela, Di Febbraro Mirko, Castiglione Silvia, Tesone Gianmarco, Raia Pasquale, Piccolo Martina   +39 more
core   +1 more source