Results 1 to 10 of about 394,077 (382)

Phenylalanine modulates casein synthesis in bovine mammary epithelial cells by influencing amino acid transport and protein synthesis pathways [PDF]

Frontiers in Nutrition
The efficiency of phenylalanine (Phe) utilization for milk protein synthesis in dairy cows is limited, and its uptake and metabolic mechanisms in the mammary tissue remaining unclear. This study investigated the effects of Phe availability (0.07, 0.14, 0.
Yuanyuan Xing, Yuanyuan Xing, Yuanyuan Xing, Yixuan Luo, Yixuan Luo, Mei Sun, Mei Sun, Jing Yang, Jing Yang, Shaoxiong Lin, Shaoxiong Lin, Xiaojia Mu, Xiaojia Mu, Xiaoyu Niu, Xiaoyu Niu, Dabiao Li, Dabiao Li, Dabiao Li, Yuanyuan Liu   +18 more
doaj   +2 more sources

Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS

Frontiers in Immunology, 2023
Acute respiratory distress syndrome (ARDS) is associated with high mortality rates in patients admitted to the intensive care unit (ICU) patients with overwhelming inflammation considered to be an internal cause.
Yiding Tang, Yue Yu, Ranran Li, Zheying Tao, Li Zhang, Xiaoli Wang, Xiaoling Qi, Yinjiaozhi Li, Tianjiao Meng, Hongping Qu, Mi Zhou, Jing Xu, Jialin Liu   +12 more
doaj   +1 more source

Anthropometry and bone mineral density in treated and untreated hyperphenylalaninemia

Endocrine Connections, 2020
Despite recent improvements in the composition of the diet, lower mineral bone density and overweight tendencies are incoherently described in patients with phenylketonuria (PKU).
Mojca Zerjav Tansek, Ana Bertoncel, Brina Sebez, Janez Zibert, Urh Groselj, Tadej Battelino, Magdalena Avbelj Stefanija   +6 more
doaj   +1 more source

Aminopeptidase C of Aspergillus niger is a Novel Phenylalanine Aminopeptidase [PDF]

, 2003
A novel enzyme with a specific phenylalanine aminopeptidase activity (ApsC) from Aspergillus niger (CBS 120.49) has been characterized. The derived amino acid sequence is not similar to any previously characterized aminopeptidase sequence but does share ...
Basten, E.J.W., Dekker, P.J.T., Schaap, P.J.   +2 more
core   +10 more sources

Differences of Phenylalanine Concentrations in Dried Blood Spots and in Plasma: Erythrocytes as a Neglected Component for This Observation

Metabolites, 2021
Monitoring phenylalanine (Phe) concentrations is critical for the management of phenylketonuria (PKU). This can be done in dried blood spots (DBS) or in EDTA plasma derived from capillary or venous blood. Different techniques are used to measure Phe, the
Dorothea Haas, Jana Hauke, Kathrin V. Schwarz, Lucia Consalvi, Friedrich K. Trefz, Nenad Blau, Georg F. Hoffmann, Peter Burgard, Sven F. Garbade, Jürgen G. Okun   +9 more
doaj   +1 more source

Amino acid δ15N underestimation of cetacean trophic positions highlights limited understanding of isotopic fractionation in higher marine consumers

Ecology and Evolution, 2020
Compound‐specific stable isotope analysis (CSIA) of amino acids (AAs) has been rapidly incorporated in ecological studies to resolve consumer trophic position (TP).
Cory J. D. Matthews, Rocio I. Ruiz‐Cooley, Corinne Pomerleau, Steven H. Ferguson   +3 more
doaj   +1 more source

AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria

Molecular Therapy: Methods & Clinical Development, 2020
Phenylketonuria (PKU) due to recessively inherited phenylalanine hydroxylase (PAH) deficiency results in hyperphenylalaninemia, which is toxic to the central nervous system. Restriction of dietary phenylalanine intake remains the standard of PKU care and
Daelyn Y. Richards, Shelley R. Winn, Sandra Dudley, Sean Nygaard, Taylor L. Mighell, Markus Grompe, Cary O. Harding   +6 more
doaj   +1 more source

Stable Isotope–Assisted Plant Metabolomics: Combination of Global and Tracer-Based Labeling for Enhanced Untargeted Profiling and Compound Annotation

Frontiers in Plant Science, 2019
Untargeted approaches and thus biological interpretation of metabolomics results are still hampered by the reliable assignment of the global metabolome as well as classification and (putative) identification of metabolites.
Maria Doppler, Christoph Bueschl, Bernhard Kluger, Andrea Koutnik, Marc Lemmens, Hermann Buerstmayr, Justyna Rechthaler, Rudolf Krska, Rudolf Krska, Gerhard Adam, Rainer Schuhmacher   +10 more
doaj   +1 more source

Polypeptide gels incorporating the exotic functional aromatic amino acid 4-amino-L-phenylalanine [PDF]

, 2018
High-molecular-weight polypeptides with functional aromatic side chains, poly(4-amino-l-phenylalanine), were prepared by the metal-initiated polymerization of the Nα-carboxyanhydride of the corresponding amino acid, which is a microbial derivative of ...
Ali, Mohammad Asif, Captain, Ilya, Deming, Timothy J, Kaneko, Tatsuo, Perlin, Pesach   +4 more
core   +1 more source

Aromatic Dipeptide Homologue-Based Hydrogels for Photocontrolled Drug Release

Nanomaterials, 2022
Peptide-based hydrogels are considered of special importance due to their biocompatibility and biodegradability. They have a wide range of applications in the biomedical field, such as drug delivery, tissue engineering, wound healing, cell culture media,
Chloé Guilbaud-Chéreau, Bhimareddy Dinesh, Laurène Wagner, Olivier Chaloin, Cécilia Ménard-Moyon, Alberto Bianco   +5 more
doaj   +1 more source