Results 1 to 10 of about 15,789 (137)
THE STRUCTURE OF THE PHENYLALANINE-HYDROXYLATION COFACTOR [PDF]
Journal of Biological Chemistry, 1963 Seymour Kaufman
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Tracking the Electron Transfer Cascade in European Robin Cryptochrome 4 Mutants [PDF]
, 2022 The primary step in the elusive ability of migratory birds to sense weak Earth-strength magnetic fields is supposedly the light-induced formation of a long-lived, magnetically sensitive radical pair inside a cryptochrome flavoprotein located in the retina of these birds.
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Comparative Roles of Charge, $π$ and Hydrophobic Interactions in Sequence-Dependent Phase Separation of Intrinsically Disordered Proteins [PDF]
Proc. Natl. Acad. Sci. U.S.A. 117, 28795-28805 (2020), 2020 Endeavoring toward a transferable, predictive coarse-grained explicit-chain model for biomolecular condensates underlain by liquid-liquid phase separation (LLPS), we conducted multiple-chain simulations of the N-terminal intrinsically disordered region (IDR) of DEAD-box helicase Ddx4, as a test case, to assess the roles of electrostatic, hydrophobic ...
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Mechanism of phenylalanine regulation of phenylalanine hydroxylase.
Journal of Biological Chemistry, 1990 The mechanism of phenylalanine regulation of rat liver phenylalanine hydroxylase was studied. We show that phenylalanine "activates" phenylalanine hydroxylase, converting it from an inactive to active form, by binding at a true allosteric regulatory site.
S H Jones, R. Shiman, D W Gray
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Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase [PDF]
Journal of Biological Chemistry, 2016 Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that requires activation by phenylalanine for full activity. The location of the allosteric site for phenylalanine has not been established. NMR spectroscopy of the isolated regulatory domain (RDPheH(25-117) is the regulatory domain of PheH lacking residues 1-24) of the rat enzyme in the ...
Paul F. Fitzpatrick, Shengnan Zhang
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Dictyostelium phenylalanine hydroxylase is activated by its substrate phenylalanine [PDF]
FEBS Letters, 2012 dicPAH and dicPAH bind by molecular sieving (View Interaction: 1, 2, 3, 4)
Soo-Woong Lee +7 more
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Poultry Science, 2009 Two experiments were done to determine the influence of Phe imbalance and excess on Phe-pyruvate aminotransferase (PAT) activity in the chick. Five replicates of 3 chicks (experiment 1) or 2 chicks (experiment 2) of a commercial brown egg layer strain were fed a semipurified diet for 1 wk and then received experimental diets for 10 d.
Richard E. Austic, J. Lu
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Efficient treatment of molecular excitations in the liquid phase environment via stochastic many-body theory [PDF]
, 2021 Accurate predictions of charge excitation energies of molecules in the disordered condensed phase are central to the chemical reactivity, stability, and optoelectronic properties of molecules and critically depend on the specific environment. Herein, we develop a stochastic GW method for calculating these charge excitation energies.
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Poultry Science, 2009 Experiments were performed to investigate the activity of hepatic Phe hydroxylase (PAH) and plasma amino acid concentrations under conditions of Phe imbalance or toxicity in chicks fed on experimental diets from 7 to 14 or 16 d of age. In experiment 1, Phe imbalance was created by adding 10% of a mixture of indispensable amino acids lacking Phe (IAA ...
Richard E. Austic, Frederick M. Lartey
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Catching proteins in liquid helium droplets [PDF]
Phys. Rev. Lett. 105, 133402 (2010), 2010 An experimental approach is presented that allows for the incorporation of large mass/charge selected ions in liquid helium droplets. It is demonstrated that droplets can be efficiently doped with a mass/charge selected amino acid as well as with the much bigger m$\approx$12 000 amu protein Cytochrome C in selected charge states.
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