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Reacting to environmental exposure, most higher plants activate secondary metabolic pathways, such as the metabolism of phenylpropanoids. This pathway results in the formation of lignin, one of the most important polymers of the plant cell, as well as a ...
Pavel Feduraev+6 more
doaj +2 more sources
Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase* [PDF]
Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that requires activation by phenylalanine for full activity. The location of the allosteric site for phenylalanine has not been established. NMR spectroscopy of the isolated regulatory domain (RDPheH(25-117) is the regulatory domain of PheH lacking residues 1-24) of the rat enzyme in the ...
Shengnan Zhang, P. Fitzpatrick
semanticscholar +3 more sources
Low temperature storage causes chilling injury in plum (Prunus domestica L.) fruits. Consequently, any treatments with beneficial effects against these symptoms would achieve attention. For this purpose, phenylalanine treatments were applied on ‘Stanley’
Ommol Banin Sogvar+3 more
doaj +2 more sources
Background Impaired metabolic functions of gut microbiota have been demonstrated in alcohol-related liver disease (ALD), but little is known about changes in phenylalanine metabolism.
Liuying Chen+5 more
semanticscholar +1 more source
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants
Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1–4.
Abhijeet Pataskar+23 more
semanticscholar +1 more source
Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ
Whether amino acids act on cellular insulin signaling remains unclear, given that increased circulating amino acid levels are associated with the onset of type 2 diabetes (T2D).
Qian Zhou+16 more
semanticscholar +1 more source
Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging
Supplemental Digital Content is available in the text. Background: Aging myocardium undergoes progressive cardiac hypertrophy and interstitial fibrosis with diastolic and systolic dysfunction.
G. Czibik+23 more
semanticscholar +1 more source
Background Dietary protein ingestion stimulates muscle protein synthesis by providing amino acids to the muscle. The magnitude and duration of the postprandial increase in muscle protein synthesis rates are largely determined by dietary protein digestion
S. Gorissen+18 more
semanticscholar +1 more source
Phenylalanine: A Promising Inducer of Fruit Resistance to Postharvest Pathogens
More than 40% of harvested fruit is lost, largely due to decay. In parallel, restrictions on postharvest fungicides call for eco-friendly alternatives.
Manish Kumar Patel+6 more
semanticscholar +1 more source
Nitrogen Economy and Nitrogen Environmental Interactions in Conifers
Efficient acquisition, assimilation and economy of nitrogen are of special importance in trees that must cope with seasonal periods of growth and dormancy over many years.
Rafael A. Cañas+4 more
doaj +1 more source