Results 11 to 20 of about 394,077 (382)

Phenylalanine Alleviates Postharvest Chilling Injury of Plum Fruit by Modulating Antioxidant System and Enhancing the Accumulation of Phenolic Compounds

Food Technology and Biotechnology, 2020
Low temperature storage causes chilling injury in plum (Prunus domestica L.) fruits. Consequently, any treatments with beneficial effects against these symptoms would achieve attention. For this purpose, phenylalanine treatments were applied on ‘Stanley’
Ommol Banin Sogvar, Vali Rabiei, Farhang Razavi, Gholamreza Gohari   +3 more
doaj   +2 more sources

Phenylalanine and Tyrosine as Exogenous Precursors of Wheat (Triticum aestivum L.) Secondary Metabolism through PAL-Associated Pathways

Plants, 2020
Reacting to environmental exposure, most higher plants activate secondary metabolic pathways, such as the metabolism of phenylpropanoids. This pathway results in the formation of lignin, one of the most important polymers of the plant cell, as well as a ...
Pavel Feduraev, Liubov Skrypnik, Anastasiia Riabova, Artem Pungin, Elina Tokupova, Pavel Maslennikov, Galina Chupakhina   +6 more
doaj   +2 more sources

Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase [PDF]

Journal of Biological Chemistry, 2016
Liver phenylalanine hydroxylase (PheH) is an allosteric enzyme that requires activation by phenylalanine for full activity. The location of the allosteric site for phenylalanine has not been established. NMR spectroscopy of the isolated regulatory domain (RDPheH(25-117) is the regulatory domain of PheH lacking residues 1-24) of the rat enzyme in the ...
Paul F. Fitzpatrick, Shengnan Zhang
openaire   +3 more sources

Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function

Cell & Bioscience, 2023
Background Impaired metabolic functions of gut microbiota have been demonstrated in alcohol-related liver disease (ALD), but little is known about changes in phenylalanine metabolism.
Liuying Chen, Pengcheng Yang, L. Hu, Ling Yang, H. Chu, Xiaohua Hou   +5 more
semanticscholar   +1 more source

Tryptophan depletion results in tryptophan-to-phenylalanine substitutants

Nature, 2022
Activated T cells secrete interferon-γ, which triggers intracellular tryptophan shortage by upregulating the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme1–4.
Abhijeet Pataskar, Julien Champagne, Remco Nagel, J. Kenski, Maarja Laos, Justine Michaux, HuiSong Pak, Onno B. Bleijerveld, Kelly Mordente, J. M. Navarro, N. Blommaert, M. M. Nielsen, Domenica Lovecchio, E. Stone, G. Georgiou, M. D. de Gooijer, O. van Tellingen, M. Altelaar, R. Joosten, A. Perrakis, J. Olweus, M. Bassani-Sternberg, D. Peeper, R. Agami   +23 more
semanticscholar   +1 more source

Phenylalanine impairs insulin signaling and inhibits glucose uptake through modification of IRβ

Nature Communications, 2022
Whether amino acids act on cellular insulin signaling remains unclear, given that increased circulating amino acid levels are associated with the onset of type 2 diabetes (T2D).
Qian Zhou, Wanbing Sun, Jia-Cong Chen, Hui‐Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Baiqing Wu, Yan-Peng An, Linshen Huang, Wen-Xing Sun, Xin-Wen Zhou, Yimin Li, Yiyuan Yuan, Jianyuan Zhao, Wei Xu, Shi-min Zhao   +16 more
semanticscholar   +1 more source

Dysregulated Phenylalanine Catabolism Plays a Key Role in the Trajectory of Cardiac Aging

Circulation, 2021
Supplemental Digital Content is available in the text. Background: Aging myocardium undergoes progressive cardiac hypertrophy and interstitial fibrosis with diastolic and systolic dysfunction.
G. Czibik, Z. Mezdari, Dogus Murat Altintas, Juliette Bréhat, M. Pini, T. d'Humières, T. Delmont, C. Radu, M. Breau, H. Liang, C. Martel, Azania Abatan, R. Sarwar, Ophélie Marion, Suzain Naushad, Yanyan Zhang, Maissa Halfaoui, N. Suffee, D. Morin, S. Adnot, S. Hatem, A. Yavari, D. Sawaki, G. Derumeaux   +23 more
semanticscholar   +1 more source

Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans

Journal of NutriLife, 2020
Background Dietary protein ingestion stimulates muscle protein synthesis by providing amino acids to the muscle. The magnitude and duration of the postprandial increase in muscle protein synthesis rates are largely determined by dietary protein digestion
S. Gorissen, J. Trommelen, I. W. Kouw, A. Holwerda, B. Pennings, Bart B L Groen, B. Wall, T. Churchward-Venne, A. Horstman, R. Koopman, N. Burd, C. Fuchs, M. Dirks, Peter T. Res, J. Senden, Jan M. Steijns, Lisette C P G M de Groot, L. Verdijk, Luc J C van Loon   +18 more
semanticscholar   +1 more source

Phenylalanine: A Promising Inducer of Fruit Resistance to Postharvest Pathogens

Foods, 2020
More than 40% of harvested fruit is lost, largely due to decay. In parallel, restrictions on postharvest fungicides call for eco-friendly alternatives.
Manish Kumar Patel, D. Maurer, O. Feygenberg, Amos Ovadia, Y. Elad, M. Oren-Shamir, N. Alkan   +6 more
semanticscholar   +1 more source

Elevated plasma phenylalanine predicts mortality in critical patients with heart failure

ESC Heart Failure, 2020
Previous studies found a relationship between elevated phenylalanine levels and poor cardiovascular outcomes. Potential strategies are available to manipulate phenylalanine metabolism.
Wei-Siang Chen, Chao-Hung Wang, Chi-Wen Cheng, Ming-hui Liu, C. Chu, Huang-Ping Wu, P. Huang, Yi-Tsen Lin, Ta Ko, Wen-Hsin Chen, Huei-Jen Wang, Shu-Chiu Lee, Chung-Yu Liang   +12 more
semanticscholar   +1 more source