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USE OF PHENYLEPHRINE HYDROCHLORIDE (NEO-SYNEPHRINE HYDROCHLORIDE(R)) IN OPHTHALMOLOGY
Archives of Ophthalmology, 1949THE FIRST studies on the ocular use of phenylephrine hydrochloride (neo-synephrine hydrochloride®) were begun in 1933 and reported in 1936.1Since then, extensive clinical experiences with this drug have accumulated with additional observations. The object of this article is to review these data, bringing them up to date.
P, HEATH, C W, GEITER
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3. Phenylenhrine Hydrochloride
Ophthalmology, 1980Phenylephrine hydrochloride is a potent, effective, relatively safe drug with few ocular side effects. Side effects from topical instillation are uncommon but include severe systemic cardiovascular effects with elevated blood pressure and stroke. Ten percent phenylephrine should be used with caution in patients with known cardiac disease, hypertension,
S M, Meyer, F T, Fraunfelder
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Journal of Clinical Pharmacy and Therapeutics, 1986
The chemical stabilities of lignocaine hydrochloride (lidocaine hydrochloride) and phenylephrine hydrochloride in a combination aqueous solution have been determined using stability-indicating high-performance liquid chromatographic methods. The drugs did not interact and were stable for at least 66 days at room temperature. The pH value changed from 6.
V, Das Gupta, K R, Stewart
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The chemical stabilities of lignocaine hydrochloride (lidocaine hydrochloride) and phenylephrine hydrochloride in a combination aqueous solution have been determined using stability-indicating high-performance liquid chromatographic methods. The drugs did not interact and were stable for at least 66 days at room temperature. The pH value changed from 6.
V, Das Gupta, K R, Stewart
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Quantitative Determinations of Phenylephrine and Phenylpropanolamine Hydrochlorides in Combination
Journal of Pharmaceutical Sciences, 1973Abstract: The quantitative determinations of phenylephrine and phenylpropanolamine hydrochlorides in combination are reported. Phenylephrine hydrochloride is assayed using the Koshy-Mitchner method without interference from phenylpropanolamine hydrochloride.
B B, Shenoy, V, Das Gupta
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Colorimetric determination of phenylephrine hydrochloride in pharmaceutical preparations
The Analyst, 1976An accurate, selective and simple method for the determination of phenylephrine hydrochloride is proposed. The method is based on the formation of the nitroso derivative of phenylephrine in the presence of copper ions.The method has been applied successfully to pharmaceutical preparations without prior separation of phenylephrine.
Y M, Dessouky, L N, Gad
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Enantioselective synthesis of (R)-phenylephrine hydrochloride
Tetrahedron Letters, 2003An efficient method for the synthesis of enantiomerically pure (R)-phenylephrine hydrochloride 1 is described using a Sharpless asymmetric dihydroxylation as the key step.
Rajesh Kumar Pandey +2 more
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Degradation of Phenylephrine Hydrochloride in Tablet Formulations Containing Aspirin
Journal of Pharmaceutical Sciences, 1964The breakdown of aspirin in tablet formulations containing phenylephrine was found to result in a concurrent loss of phenylephrine activity. Specific functional group analysis of the secondary amine function on phenylephrine was necessary to follow degradation in tablet formulations. Analyses with methods based on the phenolic function of phenylephrine
A E, TROUP, H, MITCHNER
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Determination of Phenylephrine Hydrochloride in Combination with Other Drugs
Journal of Pharmaceutical Sciences, 1968Phenylephrine is retained on an acetic acid—NaCl—diatomaceous earth column, while other amino compounds and drug excipients are eluted with chloroform acidified with acetic acid. Phenylephrine is eluted with ethyl ether and is determined by ultraviolet spectrophotometry.
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Allergic Contact Reactions due to Phenylephrine Hydrochloride in Eyedrops
Annals of Allergy, Asthma & Immunology, 1997Dermatitis of and around the eye is common. Allergic contact reactions from phenylephrine are rare despite extensive use by ophthalmologists. Previous reports do not indicate crossreactivity between phenylephrine and other sympathomimetic drugs in patch testing.We report three cases of allergic contact reactions (dermato-conjunctivitis) after eyedrops.
A, Moreno-Ancillo +4 more
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