Results 41 to 50 of about 71,907 (200)

Development and optimization of a novel sustained-release dextran tablet formulation for propranolol hydrochloride [PDF]

, 2006
A novel oral controlled delivery system for propranolol hydrochloride (PPL) was developed and optimized. The in vitro dissolution profiles of sustained-release matrix tablets of racemic PPL were determined and compared with the United States Pharmacopeia
Pedraz, José Luis, Bataille, Bernard, Iraizoz Colarte, Antonio, Rodriguez, Fernand, Castellanos Gil, Eddy, Heinämäki, Jyrki   +5 more
core   +1 more source

Correcting Axial Length‐Related Magnification Errors in Optical Coherence Tomography Angiography Improves Machine Learning Classification Performance in High Myopia

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To determine whether axial length‐related magnification correction in optical coherence tomography angiography (OCTA) improves machine learning classification of high myopia and resolves inconsistencies in the values and discriminatory power of OCTA microvascular metrics.
Danuta M. Sampson, Mila Yue Zhang, Hemn Baghban Jaldian, Madeleine S. Torcasso, Gavrielle R. Untracht, Jocelyn J. Drinkwater, Mei Zhao, David D. Sampson, Andrew Lam, Fred K. Chen   +9 more
wiley   +1 more source

Kcnv2 E151X Mouse Captures Hallmarks of KCNV2‐Associated Retinal Dystrophy

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background KCNV2‐associated retinopathy is a rare inherited retinal dystrophy caused by variants in the KCNV2 gene, leading to disrupted photoreceptor behaviour and progressive deterioration of vision. Patients have characteristic electroretinography abnormalities, including reduced cone response, delayed and reduced rod response to low light ...
Nermina Xhaferri, Sumit Biswas, Benjamin Davies, Moritz Lindner   +3 more
wiley   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Formulation and stability testing of eye drop preparations containing phenylephrine hydrochloride [PDF]

, 2012
Phenylephrine hydrochloride is a potent adrenergic agent and β-receptor sympathomimetic drug, used in its optically active form (Pandey et al., 2003; Pandey et al., 2006). As an α1-adrenergic receptor agonist, phenylephrine hydrochloride is used ocularly
Okafor, Chinedum Oluchukwu
core  

A practical synthesis of (R)-(−)-phenylephrine hydrochloride

, 1998
(R)-(−)-Phenylephrine hydrochloride is a clinically potent adrenergic agent and B-receptor sympathomimetic drug, exclusively marketed in the optically active form.
Chorghade, Mukund S., Krishna, L. Murali, Gurjar, Mukund K., Sarma, B. S., Bugga, V. N.   +4 more
core   +1 more source

The single use lidocaine hydrochloride 0.5 per cent w/v and phenylephrine hydrochloride 0.5 percent w/v topical spray, can it now be employed as a multi-use atomiser?

, 2020
Objective: This study investigated the risk of contamination of lidocaine hydrochloride 5 per cent w/v and phenylephrine hydrochloride 0.5 per cent w/v topical solution after modification of the application technique.Methods: This paper reports a ...
Zudovaite, Inga, Singh, Tahwinder, Jog, Mandar, O'Dwyer, Matthew, Saeed, Kordo   +4 more
core   +1 more source

Effect of 1-acyl-5,6-dimethoxy / diethoxy-2-methylthiobenzimidazoles on APD90 and isometric contraction in guinea pig atrium and aortic preparations activated by carbachol and phenylephrine

Acta Medica Lituanica, 2010
Studies have shown that 1-acyl-5,6-diethoxy-2-methylthiobenzimidazole derivatives 3-pyridyl-(1); 2-pyridyl- (2); 4-thiazolyl- (3); 4-pyridyl- (4); methyl- (5); 2-thienyl- (6) and 1-acetyl-5,6-dimethoxy-2-methylthiobenzimidazole (7) exhibit positive ...
Vida GARALIENĖ, Linas LABANAUSKAS, Algirdas BRŪKŠTUS, Vygantas BARSYS   +3 more
doaj   +1 more source

Is It Safe to Use Vasoconstrictors in Association Treated with Amitriptyline or Can It Potentiate Cardiovascular Effects? In Vivo Animal Study

Applied Sciences, 2022
This study aimed to evaluate changes in blood pressure of rats treated or not with amitriptyline after infiltration in the buccal sulcus and intravenous injection of epinephrine, felypressin and phenylephrine in equivalent doses (ED) to the amounts ...
Gabriela Moraes Oliveira, Thiago José Dionísio, Camila Assis Fleury, Adriana Maria Calvo, Carlos Ferreira Santos, Flavio Augusto Cardoso Faria   +5 more
doaj   +1 more source

The Effects of Nasal and Multi‐Level Upper Airway Surgery on Upper Airway Collapsibility and Non‐Anatomical Endotypes in People With Obstructive Sleep Apnoea—A Pilot Study

Journal of Sleep Research, EarlyView.
ABSTRACT Nasal breathing is the preferred route of breathing during sleep. Indeed, nasal blockage can cause obstructive sleep apnoea (OSA) in otherwise healthy people. Whilst multi‐level pharyngeal surgery reduces OSA severity, efficacy varies and changes in OSA pathophysiology post‐surgery have not been well characterised.
Amal M. Osman, A. Simon Carney, Himani Joshi, Phuc Nguyen, Peter Catcheside, Eng H. Ooi, Danny J. Eckert   +6 more
wiley   +1 more source