Results 41 to 50 of about 8,440 (203)

Evaluation of the bioequivalence of two formulations containing the combination of 400 mg of acetaminophen (paracetamol), 4 mg of phenylephrine and 4 mg of chlorpheniramine in capsules: open-label, three-way crossover study, partially replicated in healthy volunteers of both sexes

Brazilian Journal of Pharmaceutical Sciences, 2020
This study was carried out in order to compare the relative bioavailability of two different formulations containing 400 mg of acetaminophen + 4 mg of phenylephrine hydrochloride + 4 mg of chlorpheniramine maleate, Test formulation (Cimegripe®) and ...
Alessandra Ferreira dos Santos, Quevellin Alves dos Santos, Carlos Eduardo Melo Correa, Edvaldo Capobiango Coelho   +3 more
doaj   +1 more source

A practical synthesis of (R)-(−)-phenylephrine hydrochloride

, 1998
(R)-(−)-Phenylephrine hydrochloride is a clinically potent adrenergic agent and B-receptor sympathomimetic drug, exclusively marketed in the optically active form.
Chorghade, Mukund S., Krishna, L. Murali, Gurjar, Mukund K., Sarma, B. S., Bugga, V. N.   +4 more
core   +1 more source

The single use lidocaine hydrochloride 0.5 per cent w/v and phenylephrine hydrochloride 0.5 percent w/v topical spray, can it now be employed as a multi-use atomiser?

, 2020
Objective: This study investigated the risk of contamination of lidocaine hydrochloride 5 per cent w/v and phenylephrine hydrochloride 0.5 per cent w/v topical solution after modification of the application technique.Methods: This paper reports a ...
Zudovaite, Inga, Singh, Tahwinder, Jog, Mandar, O'Dwyer, Matthew, Saeed, Kordo   +4 more
core   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

Cardiovascular effects of dobutamine, norepinephrine and phenylephrine in isoflurane-anaesthetized dogs administered dexmedetomidine–vatinoxan [PDF]

, 2022
Objective: To determine whether dobutamine, norepinephrine or phenylephrine infusions alleviate hypotension in isoflurane-anaesthetized dogs administered dexmedetomidine with vatinoxan. Study design: Balanced, randomized crossover trial. Animals: A total
Tommi Pesonen, Flavia Restitutti, Huuskonen, Vilhelmiina, Juhana Honkavaara, Vilhelmiina Huuskonen, Outi Vainio, Restitutti, Flavia, Raekallio, Marja, Pesonen, Tommi, Vainio, Outi, Honkavaara, Juhana, Marja Raekallio   +11 more
core   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Bilateral simultaneous cataract surgery and intraocular lens implantation in an adult female chimpanzee (Pan troglodytes) inducing monovision

Veterinary Ophthalmology, Volume 28, Issue 2, Page 457-464, March 2025.
Abstract Background Cataract is the major cause of visual impairment in humans. Phacoemulsification with intraocular lens (IOL) implantation is the standard technique for cataract treatment with a high success rate. In a few cases, the surgical cataract procedure and lens implantation have been applied in non‐human primates.
F. Notting, Y. Cheng, M. Marinkovic, H. van Bolhuis, I. Notting   +4 more
wiley   +1 more source

Traction suture fixation technique using a capsular tension ring fragment for severe lens displacement during cataract surgery in dogs

Veterinary Ophthalmology, Volume 28, Issue 2, Page 197-206, March 2025.
Abstract Objectives To describe the traction suture fixation technique for severely displaced lenses (≥180°) using a capsular tension ring (CTR) fragment during cataract surgery in dogs, and to retrospectively investigate its clinical outcomes. Animals Studied Eight dogs (nine eyes). Procedures The medical records of dogs with severe lens displacement (
Shinya Fukumoto, Tomomi Minamoto
wiley   +1 more source

APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function

The Journal of Physiology, EarlyView.
Abstract figure legend We examined the interaction effect of ovarian hormones and APOE genotype on cerebrovascular and mitochondrial function. Our data revealed that APOEε3 mice that were ovariectomized exhibited impaired endothelial function and greater oxidative stress and inflammation compared to sham controls.
Mackenzie N. Kehmeier, Alexandra Famiano, Abigail E. Cullen, Thomas Leonhardt, Skylyn J. Ferguson, Madeleine Snyder, Carrie E. McCurdy, Daniel J. Tyrrell, Nabil J. Alkayed, Ashley E. Walker   +9 more
wiley   +1 more source

Effect of 1-acyl-5,6-dimethoxy / diethoxy-2-methylthiobenzimidazoles on APD90 and isometric contraction in guinea pig atrium and aortic preparations activated by carbachol and phenylephrine

Acta Medica Lituanica, 2010
Studies have shown that 1-acyl-5,6-diethoxy-2-methylthiobenzimidazole derivatives 3-pyridyl-(1); 2-pyridyl- (2); 4-thiazolyl- (3); 4-pyridyl- (4); methyl- (5); 2-thienyl- (6) and 1-acetyl-5,6-dimethoxy-2-methylthiobenzimidazole (7) exhibit positive ...
Vida GARALIENĖ, Linas LABANAUSKAS, Algirdas BRŪKŠTUS, Vygantas BARSYS   +3 more
doaj   +1 more source