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Phenytoin‐Lipid Conjugates as Potential Prodrugs of Phenytoin
Archiv der Pharmazie, 1993AbstractPhenytoin‐1‐triglycerides and phenytoin‐2‐triglycerides were synthesized as potential prodrugs of phenytoin by covalent binding of 3‐hydroxymethylphenytoin by succinic acid to the positions 1 and 2 of diglycerides, respectively. The corresponding 1‐ and 2‐monoglycerides were prepared.
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Journal of Allergy and Clinical Immunology, 1980
S H, Josephs, S J, Rothman, R H, Buckley
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S H, Josephs, S J, Rothman, R H, Buckley
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Phenytoin: neuroprotection or neurotoxicity?
Neurological Sciences, 2017J. K. Keppel Hesselink, D. J. Kopsky
semanticscholar +1 more source
2018
Phenytoin is a first-generation antiepileptic drug characterized by a good range of antiepileptic indications, with an acceptable interaction profile in polytherapy. The reasons for the decreased use of phenytoin in patients with epilepsy include its narrow therapeutic index and potential for long-term toxicity, as well as the development of other ...
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Phenytoin is a first-generation antiepileptic drug characterized by a good range of antiepileptic indications, with an acceptable interaction profile in polytherapy. The reasons for the decreased use of phenytoin in patients with epilepsy include its narrow therapeutic index and potential for long-term toxicity, as well as the development of other ...
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Cardiovascular adverse effects of phenytoin
Journal of Neurology, 2015B. Guldiken +3 more
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Comparison of cubosomes and hexosomes for the delivery of phenytoin to the brain
Journal of Colloid and Interface Science, 2022Ben J Boyd
exaly